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  • January 2023
  • Case

Cleave Therapeutics: Taking a Risk on Oncology Drug Discovery
By: Regina Herzlinger and Brian Walker
How can a successful executive assess her next move as the CEO of a firm with a promising and yet uncertain new drug? Amy Burroughs’ mandate to find a therapeutic window for Cleave Therapeutics oncology drug was on track but faced an uncertain future. Overseeing the...  View Details
Keywords: Product Development; Leadership; Health Testing and Trials; Research and Development; Risk and Uncertainty; Financial Condition; Partners and Partnerships; Pharmaceutical Industry
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  • 2022
  • Working Paper

Laboratory Safety and Research Productivity
By: Alberto Galasso, Hong Luo and Brooklynn Zhu
Are laboratory safety practices a tax on scientific productivity? We examine this question by exploiting the substantial increase in safety regulations at the University of California following the shocking accidental death of a research assistant in 2008....  View Details
Keywords: Economics Of Science; Risk Perception; Safety Regulations; Safety; Working Conditions; Governing Rules, Regulations, and Reforms; Innovation and Invention
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  • May 2022
  • Case

Timnit Gebru: 'SILENCED No More' on AI Bias and The Harms of Large Language Models
By: Tsedal Neeley and Stefani Ruper
Dr. Timnit Gebru—a leading artificial intelligence (AI) computer scientist and co-lead of Google’s Ethical AI team—was messaging with one of her colleagues when she saw the words: “Did you resign?? Megan sent an email saying that she accepted your resignation.” Heart...  View Details
Keywords: Ethics; Employment; Corporate Social Responsibility and Impact; Technological Innovation
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  • 2022
  • Working Paper

The Disagreement Problem in Explainable Machine Learning: A Practitioner's Perspective
By: Satyapriya Krishna, Tessa Han, Alex Gu, Javin Pombra, Shahin Jabbari, Steven Wu and Himabindu Lakkaraju
As various post hoc explanation methods are increasingly being leveraged to explain complex models in high-stakes settings, it becomes critical to develop a deeper understanding of if and when the explanations output by these methods disagree with each other, and how...  View Details
Keywords: AI and Machine Learning; Analytics and Data Science; Mathematical Methods
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  • February 2022 (Revised September 2022)
  • Case

InstaDeep: AI Innovation Born in Africa (A)
By: Shikhar Ghosh and Esel Çekin
Karim Beguir and Zohra Slim were the co-founders of InstaDeep, a deep tech startup focusing on artificial intelligence (AI) solutions. Instadeep was one of the few companies globally that were partnering with DeepMind, an AI subsidiary of Google [Alphabet Inc.]....  View Details
Keywords: AI; Artificial Intelligence; Entrepreneurship; Operations; Business Subsidiaries; Brands and Branding; Innovation and Invention; Growth and Development Strategy; AI and Machine Learning; Technology Industry; Africa
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  • February 2022 (Revised July 2022)
  • Supplement

InstaDeep: AI Innovation Born in Africa (B)
By: Shikhar Ghosh and Esel Çekin
Karim Beguir and Zohra Slim were the co-founders of InstaDeep, a deep tech startup focusing on artificial intelligence (AI) solutions. Instadeep was one of the few companies globally that were partnering with DeepMind, an AI subsidiary of Google [Alphabet Inc.]....  View Details
Keywords: AI; Artificial Intelligence; Entrepreneurship; Operations; Business Subsidiaries; Brands and Branding; Innovation and Invention; Growth and Development Strategy; AI and Machine Learning; Technology Industry; Africa
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  • Article

Megastudies Improve the Impact of Applied Behavioural Science
By: Katherine L. Milkman, Dena Gromet, Hung Ho, Joseph S. Kay, Timothy W. Lee, Pepi Pandiloski, Yeji Park, Aneesh Rai, Max Bazerman, John Beshears, Lauri Bonacorsi, Colin Camerer, Edward Chang, Gretchen Chapman, Robert Cialdini, Hengchen Dai, Lauren Eskreis-Winkler, Ayelet Fishbach, James J. Gross, Samantha Horn, Alexa Hubbard, Steven J. Jones, Dean Karlan, Tim Kautz, Erika Kirgios, Joowon Klusowski, Ariella Kristal, Rahul Ladhania, Jens Ludwig, George Loewenstein, Barbara Mellers, Sendhil Mullainathan, Silvia Saccardo, Jann Spiess, Gaurav Suri, Joachim H. Talloen, Jamie Taxer, Yaacov Trope, Lyle Ungar, Kevin G. Volpp, Ashley Whillans, Jonathan Zinman and Angela L. Duckworth
Policy-makers are increasingly turning to behavioural science for insights about how to improve citizens’ decisions and outcomes. Typically, different scientists test different intervention ideas in different samples using different outcomes over different time...  View Details
Keywords: Policy Making; Behavioral Science; Behavior; Change; Decision Making; Policy
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  • November 2021 (Revised May 2022)
  • Case

QuantumScape's Mission to Revolutionize Energy Storage for a Sustainable Future
By: William A. Sahlman, Allison M. Ciechanover and Jeff Huizinga
QuantumScape CEO Jagdeep Singh juggles the many activities required to lead the next-generation battery pioneer. Founded in 2010, QuantumScape’s mission was to develop new “solid-state” car batteries that would improve upon traditional lithium-ion batteries in key...  View Details
Keywords: Batteries; Electric Vehicles; SPACs; Innovation and Management; Technological Innovation; Science-Based Business; Environmental Sustainability; Auto Industry; Energy Industry; California; San Jose
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  • Article

Potentially Long-Lasting Effects of the Pandemic on Scientists
By: Jian Gao, Yian Yin, Kyle R. Myers, Karim R. Lakhani and Dashun Wang
Two surveys of principal investigators conducted between April 2020 and January 2021 reveal that while the COVID-19 pandemic’s initial impacts on scientists’ research time seem alleviated, there has been a decline in the rate of initiating new projects. This dimension...  View Details
Keywords: COVID-19; Scientists; Scientific Research; Health Pandemics; Research; Gender
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  • June 2021
  • Case

uBiome
By: Thomas R. Eisenmann and Olivia Graham
uBiome provided clinical tests that sequenced the DNA of human microbiome samples, providing data on health conditions directly to consumers or to prescribing physicians. Founded in 2012, the San Francisco-based startup raised $105 million from top-tier venture capital...  View Details
Keywords: Business Startups; Crime and Corruption; Insolvency and Bankruptcy
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  • June 2021
  • Article

Engineering Serendipity: When Does Knowledge Sharing Lead to Knowledge Production?
By: Jacqueline N. Lane, Ina Ganguli, Patrick Gaule, Eva C. Guinan and Karim R. Lakhani
We investigate how knowledge similarity between two individuals is systematically related to the likelihood that a serendipitous encounter results in knowledge production. We conduct a natural field experiment at a medical research symposium, where we exogenously...  View Details
Keywords: Cognitive Similarity; Innovation; Knowledge Production; Natural Field Experiment; Knowledge Acquisition; Knowledge Sharing; Relationships
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  • Article

GitLab: Work Where You Want, When You Want
By: Prithwiraj Choudhury, Kevin Crowston, Linus Dahlander, Marco S. Minervini and Sumita Raghuram
GitLab is a software company that works “all remote” at the scale of more than 1,000 employees located in more than 60 countries. GitLab has no physical office and its employees can work from anywhere they choose. Any step of the organizational life of a GitLab...  View Details
Keywords: New Forms Of Organizing; Remote Work; All Remote; Virtual Organizations; COVID-19; Organizational Design; Employees; Geographic Location; Health Pandemics
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  • October 2020
  • Article

The Elasticity of Science
By: Kyle Myers
This paper identifies the degree to which scientists are willing to change the direction of their work in exchange for resources. Data from the National Institutes of Health are used to estimate how scientists respond to targeted funding opportunities. Inducing a...  View Details
Keywords: Scientists; Funding; Research; Change
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  • September 2020
  • Article

Unequal Effects of the COVID-19 Pandemic on Scientists
By: Kyle Myers, Wei Yang Tham, Yian Yin, Nina Cohodes, Marie Thursby, Jerry Thursby, Peter Schiffer, Joseph Walsh, Karim R. Lakhani and Dashun Wang
COVID-19 has not affected all scientists equally. A survey of principal investigators indicates that female scientists, those in the ‘bench sciences’ and, especially, scientists with young children experienced a substantial decline in time devoted to research. This...  View Details
Keywords: COVID-19; Scientists; Health Pandemics; Gender; Personal Development and Career
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  • Article

The Importance of Being Causal
By: Iavor I Bojinov, Albert Chen and Min Liu
Causal inference is the study of how actions, interventions, or treatments affect outcomes of interest. The methods that have received the lion’s share of attention in the data science literature for establishing causation are variations of randomized experiments....  View Details
Keywords: Causal Inference; Observational Studies; Cross-sectional Studies; Panel Studies; Interrupted Time-series; Instrumental Variables
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  • March 21, 2020
  • Editorial

When We're Wrong, It's Our Responsibility as Scientists to Say So
By: Ariella S. Kristal, A.V. Whillans, Max Bazerman, Francesca Gino, Lisa Shu, Nina Mazar and Dan Ariely
We tried to reproduce our 2012 paper on how to make people report their income more honestly—and we ended up refuting it.  View Details
Keywords: Responsibility; Outcome or Result
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  • March 2020
  • Article

Do Managers Matter? A Natural Experiment from 42 R&D Labs in India
By: Prithwiraj Choudhury, Tarun Khanna and Christos A. Makridis
We exploit plausibly exogenous variation in the staggered entry of new managers into India’s 42 public R&D labs between 1994 and 2006 to study how alignment between the CEO and middle-level managers affect research productivity. We show that the introduction of new lab...  View Details
Keywords: Incentives; Innovation; Productivity; Management; Alignment; Research and Development; Innovation and Invention; Performance Productivity; India
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  • January 2020
  • Case

The Origins of Bell Labs
By: Tom Nicholas and John Masko
In 1947, scientists at Bell Labs invented the transistor—a tiny signal amplifier that would go on to become the fundamental building block of the digital age. But, confounding most traditional economic assumptions, it was not a vigorous startup that made this momentous...  View Details
Keywords: Business History; Innovation Leadership; Technological Innovation; Patents; Monopoly; Organizational Structure; Competitive Strategy; Telecommunications Industry; Boston; Massachusetts; New York (city, NY)
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  • November 2019
  • Case

The Genesis Lab at Novartis
By: Amy C. Edmondson, Ranjay Gulati, Patrick J. Healy and Kerry Herman
Novartis' Genesis Labs program, launched in 2016 as part of Novartis Institutes for Biomedical Research (NIBR), hosted pitch competitions where teams of NIBR scientists proposed ideas to explore that aimed to revolutionize drug discovery. The goal was to break down...  View Details
Keywords: Drug Discovery; Health Care and Treatment; Research and Development; Innovation and Invention; Programs; Management
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  • 2020
  • Working Paper

Engineering Serendipity: When Does Knowledge Sharing Lead to Knowledge Production?
By: Jacqueline N. Lane, Ina Ganguli, Patrick Gaule, Eva C. Guinan and Karim R. Lakhani
We investigate how knowledge similarity between two individuals is systematically related to the likelihood that a serendipitous encounter results in knowledge production. We conduct a natural field experiment at a medical research symposium, where we exogenously...  View Details
Keywords: Cognitive Similarity; Knowledge Creation; Knowledge Sharing; Knowledge Dissemination; Relationships
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