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- May 2025
- Case
Daiichi Sankyo: Steering a Global Organization
In the spring of 2023, Sunao Manabe, CEO of Daiichi Sankyo, reflected on a pivotal decision. A large Western pharmaceutical company had made a bid to partner with Daiichi Sankyo to develop the next three products in its oncology pipeline. Daiichi Sankyo, a 125-year old... View Details
Keywords: Strategy; Culture Change; Decision-making; Leadership; Culture; Innovation; Psychological Safety
- December 5, 2024
- Article
A Consensus Definition of Creativity in Surgery: A Delphi Study Protocol
By: Alex Thabane, Tyler McKechnie, Phillip Staibano, Vikram Arora, Goran Calic, Jason W. Busse, Sameer Parpia and Mohit Bhandari
Introduction
Clear definitions are essential in science, particularly in the study of abstract phenomena like creativity. Due to its inherent complexity and domain-specific nature, the study of creativity has been complicated, as evidenced by the various... View Details
Clear definitions are essential in science, particularly in the study of abstract phenomena like creativity. Due to its inherent complexity and domain-specific nature, the study of creativity has been complicated, as evidenced by the various... View Details
- November 2024
- Supplement
AlphaGo (C): Birth of a New Intelligence
By: Shikhar Ghosh and Shweta Bagai
This case, the final of a three-part series, explores DeepMind's pivotal transition from mastering games to solving real-world scientific challenges. In December 2020, DeepMind's AI system AlphaFold 2 achieved a breakthrough by solving protein folding—a 50-year-old... View Details
Keywords: Autonomy; Deep Learning; Drug Discovery; Healthcare Innovation; Neural Networks; Scientific Research; Technology Startup; AI and Machine Learning; Technological Innovation; Research and Development; Business Model; Business Strategy; Open Source Distribution; Technology Industry; United States
- September 2024
- Article
Standing on the Shoulders of Science
By: Joshua Lev Krieger, Monika Schnitzer and Martin Watzinger
Today’s innovations rely on scientific discoveries of the past, yet only some corporate
R&D builds directly on scientific output. In this paper, we analyze U.S. patents to
investigate how firms generate value by building on prior art “closer” to science. We
show... View Details
- July 24, 2024
- Article
Research: How Passion Can Backfire at Work
By: Erica R. Bailey, Kai Krautter, Wen Wu, Adam D. Galinsky and Jon M. Jachimowicz
Passion has long been championed as a key to workplace success. However, scientific studies have found mixed results: On the one hand, some studies find evidence that passionate employees tend to perform better, while other research has documented null or even negative... View Details
- April 2024 (Revised December 2024)
- Case
Anthropic: Building Safe AI
By: Shikhar Ghosh and Shweta Bagai
In late 2024, Anthropic, a leading AI safety and research company, achieved a significant breakthrough with computer use capabilities that allowed AI to interact with computers like humans. Co-founded by former OpenAI employees and known for its generative AI... View Details
- March 2024
- Article
Being Together in Place as a Catalyst for Scientific Advance
By: Eamon Duede, Misha Teplitskiy, Karim R. Lakhani and James Evans
The COVID-19 pandemic necessitated social distancing at every level of society, including universities and research institutes, raising essential questions concerning the continuing importance of physical proximity for scientific and scholarly advance. Using customized... View Details
- 2024
- Working Paper
The Wandering Scholars: Understanding the Heterogeneity of University Commercialization
By: Josh Lerner, Henry Manley, Carolyn Stein and Heidi Williams
University-based scientific research has long been argued to be a central source of
commercial innovation and economic growth. Yet at the same time, there have been
long-held concerns that many university-based discoveries never realize their potential
social... View Details
- 2024
- Working Paper
Bootstrap Diagnostics for Irregular Estimators
By: Isaiah Andrews and Jesse M. Shapiro
Empirical researchers frequently rely on normal approximations in order to summarize and communicate uncertainty about their findings to their scientific audience. When such approximations are unreliable, they can lead the audience to make misguided decisions. We... View Details
- October–December 2023
- Article
A Practical Guide to Conversation Research: How to Study What People Say to Each Other
By: Michael Yeomans, Katelynn Boland, Hanne K. Collins, Nicole Abi-Esber and Alison Wood Brooks
Conversation—a verbal interaction between two or more people—is a complex, pervasive, and consequential human behavior. Conversations have been studied across many academic disciplines. However, advances in recording and analysis techniques over the last decade have... View Details
- 2025
- Working Paper
Bringing Science to Market: Knowledge Foundations, Inventor-Founders, and Performance
By: Justine Boudou and Maria Roche
In this paper, we examine how a startup’s knowledge foundations—embedded in its
core technology—influence its performance in the exit market. Using a dataset of 1,006
biomedicine startups founded between 2005 and 2015, we focus on two key factors: (1)
the degree of... View Details
- 2023
- Working Paper
Mapping Organizational-Level Networks Using Individual-Level Connections: Evidence from Online Professional Networks
By: Shelley Xin Li, Frank Nagle and Aner Zhou
Organization-level networks facilitate the flow of information and business activities in the
economy. Prior research relies solely on high-level connections to measure these networks. Therefore, to
understand the role of employee connections at all job levels in... View Details
- April 5, 2023
- Article
We Need an Operation Warp Speed for Long COVID
By: Esther K. Choo and Scott Duke Kominers
With millions of people affected and at least $1 trillion of economic value at stake, long COVID is our next national health emergency. View Details
- March, 2023
- Article
Academic Entrepreneurship: Entrepreneurial Advisors and Their Advisees' Outcomes
By: Maria P. Roche
The transfer of complex knowledge and skills is difficult, often requiring intensive interaction and extensive periods of co-working between a mentor and mentee, which is particularly true in apprenticeship-like settings and on-the-job training. This paper studies a... View Details
- November 22, 2022
- Article
Is Novel Research Worth Doing? Evidence from Peer Review at 49 Journals
By: Misha Teplitskiy, Hao Peng, Andrea Blasco and Karim R. Lakhani
There are long-standing concerns that peer review, which is foundational to scientific institutions like journals and funding agencies, favors conservative ideas over novel ones. We investigate the association between novelty and the acceptance of manuscripts submitted... View Details
- November 2022 (Revised December 2024)
- Case
Hugging Face (A): Serving AI on a Platform
By: Shane Greenstein, Daniel Yue, Sarah Gulick and Kerry Herman
It is fall 2022, and open-source AI model company Hugging Face is considering its three areas of priorities: platform development, supporting the open-source community, and pursuing cutting-edge scientific research. As it expands services for enterprise clients, which... View Details
- Editorial
Zeroing Out on zero-COVID
By: William C. Kirby
China’s culture reveres science, yet operates under a government that often defines what “science” is and is not. China’s “zero-COVID” policy has created a bifurcated scientific community that threatens international collaboration in science and technology. A... View Details
- June 2022
- Article
Conservatism Gets Funded? A Field Experiment on the Role of Negative Information in Novel Project Evaluation
By: Jacqueline N. Lane, Misha Teplitskiy, Gary Gray, Hardeep Ranu, Michael Menietti, Eva C. Guinan and Karim R. Lakhani
The evaluation and selection of novel projects lies at the heart of scientific and technological innovation, and yet there are persistent concerns about bias, such as conservatism. This paper investigates the role that the format of evaluation, specifically information... View Details
- May 2022
- Article
How Status of Research Papers Affects the Way They Are Read and Cited
By: Misha Teplitskiy, Eamon Duede, Michael Menietti and Karim R. Lakhani
Although citations are widely used to measure the influence of scientific works, research shows that many citations serve rhetorical functions and reflect little-to-no influence on the citing authors. If highly cited papers disproportionately attract rhetorical... View Details
Keywords: Metrics; Influence; Status; Citations; Science; Measurement and Metrics; Research; Perception
- April 27, 2022
- Article
Inequality in Researchers' Minds: Four Guiding Questions for Studying Subjective Perceptions of Economic Inequality
By: Jon M. Jachimowicz, Shai Davidai, Daniela Goya-Tocchetto, Barnabas Szaszi, Martin Day, Stephanie Tepper, L. Taylor Phillips, M. Usman Mirza, Nailya Ordabayeva and Oliver P. Hauser
Subjective perceptions of inequality can substantially influence policy attitudes, public health metrics, and societal well-being, but the lack of consensus in the scientific community on how to best operationalize and measure these perceptions may impede progress on... View Details