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  • May 2021
  • Case

The SMA Foundation: Steering Therapeutic Research and Development in a Rare Disease
By: Amitabh Chandra, Spencer Lee-Rey and Caroline Marra
This case explores incentives for rare disease drug development by chronicling the role of the Spinal Muscular Atrophy (SMA) Foundation in forming strategic partnerships with the scientific research community and pharmaceutical developers to transform the trajectory...  View Details
Keywords: Innovation and Invention; Strategy; Business or Company Management; Society; Health; Public Administration Industry; Health Industry; United States
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  • May, 2021
  • Article

Joy and Rigor in Behavioral Science
By: Hanne K. Collins, Ashley V. Whillans and Leslie K. John
In the past decade, behavioral science has seen the introduction of beneficial reforms to reduce false positive results. Serving as the motivational backdrop for the present research, we wondered whether these reforms might have unintended negative consequences on...  View Details
Keywords: Open Science; Pre-registration; Exploration; Confirmation; False Positives; Career Satisfaction; Science; Research; Personal Development and Career; Satisfaction; Diversity
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  • February 2021
  • Case

Marie Curie: Changing the World
By: Robert L. Simons and Shirley Sun
This case describes the rise of Marie Curie from a poor family in Poland to the pinnacle of scientific fame. The case describes how Curie, as a young woman interested in science, found a way to earn a doctorate at the Sorbonne and perform pathbreaking research on...  View Details
Keywords: Science; Research; Personal Characteristics; Mission and Purpose; Success; Work-Life Balance; Higher Education; Personal Development and Career
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  • Article

Assessing the Food and Drug Administration's Risk-Based Framework for Software Precertification with Top Health Apps in the United States: Quality Improvement Study
By: Noy Alon, Ariel Dora Stern and John Torous
BACKGROUND: As the development of mobile health apps continues to accelerate, the need to implement a framework that can standardize categorizing these apps to allow for efficient, yet robust regulation grows. However, regulators and researchers are faced with numerous...  View Details
Keywords: Mobile Health; Smartphone; Food And Drug Administration; Risk-based Framework; Health Care and Treatment; Mobile Technology; Software
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  • 2020
  • Working Paper

When Do Experts Listen to Other Experts? The Role of Negative Information in Expert Evaluations for Novel Projects
By: Jacqueline N. Lane, Misha Teplitskiy, Gary Gray, Hardeep Ranu, Michael Menietti, Eva C. Guinan and Karim R. Lakhani
The evaluation of novel projects lies at the heart of scientific and technological innovation, and yet literature suggests that this process is subject to inconsistency and potential biases. This paper investigates the role of information sharing among experts as the...  View Details
Keywords: Project Evaluation; Innovation; Knowledge Frontier; Negativity Bias; Projects; Innovation and Invention; Information; Diversity; Judgments
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  • 2020
  • Working Paper

Scientific Production: An Exploration into Organization, Resource Allocation, and Funding
By: Jerry Thursby, Marie Thursby, Karim R. Lakhani, Kyle R. Myers, Nina Cohodes, Sarah Bratt, Dennis Byrski, Hannah Cohoon and Maria Roche
Production of scientific knowledge is core to civilizational advancement in economic and material wellbeing of societies. Despite its fundamental importance, however, a systematic effort to quantitatively study the factors underlying scientific production, particularly...  View Details
Keywords: Funding; Science; Knowledge; Research; Information Management; Resource Allocation
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  • March 2020
  • Case

ZEISS Group: Organize by Customer Culture?
By: Willy C. Shih
How should ZEISS, the German manufacturer of precision optical and optoelectronic systems manage two historic businesses that operated fairly autonomously? The Industrial Quality Solutions (IQS) business sold measurement equipment to manufacturing companies in sectors...  View Details
Keywords: Organizational Structure; Organizational Culture; Manufacturing Industry; Europe; Germany
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  • September 2019
  • Case

Dementia Discovery Fund
By: Richard G. Hamermesh, Kathy Giusti and Sarah Gulick
The case is set in March 2019, and tells the story of the founding of the Dementia Discovery Fund (DDF). The idea for the fund began in 2015, when then-Prime Minister David Cameron spoke about the importance of making breakthroughs in dementia research, and pledged...  View Details
Keywords: Venture Capital; Investment Funds; Mission and Purpose; Recruitment; Health Care and Treatment; Pharmaceutical Industry; Financial Services Industry; Boston; Massachusetts; London; England
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  • July 2019
  • Article

'Forward Flow': A New Measure to Quantify Free Thought and Predict Creativity
By: Kurt Gray, Stephen Anderson, Eric Evan Chen, John Michael Kelly, Michael S. Christian, John Patrick, Laura Huang, Yoed N. Kenett and Kevin Lewis
When the human mind is free to roam, its subjective experience is characterized by a continuously evolving stream of thought. Although there is a technique that captures people’s streams of free thought—free association—its utility for scientific research is undermined...  View Details
Keywords: Cognition and Thinking; Creativity; Forecasting and Prediction
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  • 2019
  • Chapter

Characterizing the Drug Development Pipeline for Precision Medicines
By: Amitabh Chandra, Craig Garthwaite and Ariel Dora Stern
BOOK ABSTRACT: Personalized and precision medicine (PPM)—the targeting of therapies according to an individual’s genetic, environmental, or lifestyle characteristics—is becoming an increasingly important approach in health care treatment and prevention. The advancement...  View Details
Keywords: Healthcare; Precision Medicine
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  • Article

The Career Effects of Scandal: Evidence from Scientific Retractions
By: Pierre Azoulay, Alessandro Bonatti and Joshua Lev Krieger
We investigate how the scientific community's perception of a scientist's prior work changes when one of his articles is retracted. Relative to non-retracted control authors, faculty members who experience a retraction see the citation rate to their earlier,...  View Details
Keywords: Reputation; Perception; Status and Position; Outcome or Result
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  • Article

A Field Experiment on Search Costs and the Formation of Scientific Collaborations
By: Kevin Boudreau, Tom Brady, Ina Ganguli, Patrick Gaule, Eva C. Guinan, Anthony Hollenberg and Karim R. Lakhani
We present the results of a field experiment conducted at Harvard Medical School to understand the extent to which search costs affect matching among scientific collaborators. We generated exogenous variation in search costs for pairs of potential collaborators by...  View Details
Keywords: Search Costs; Cost; Marketplace Matching; Groups and Teams; Science; Collaborative Innovation and Invention
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  • September 2017
  • Case

Sensing (and Monetizing) Happiness at Hitachi
By: Ethan Bernstein and Stephanie Marton
Inspired by research linking happiness and productivity, Hitachi had invested in developing new “people analytics” technologies to help companies increase employee happiness. Hitachi had begun manufacturing high-tech badges that quantify a wearer’s activity patterns....  View Details
Keywords: People Analytics; Japan; Sociometers; Wearables; Interpersonal Communication; Human Resources; Happiness; Technology Industry; Japan
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  • Winter 2017
  • Article

Why Big Data Isn't Enough
By: Sen Chai and Willy C. Shih
There is a growing belief that sophisticated algorithms can explore huge databases and find relationships independent of any preconceived hypotheses. But in businesses that involve scientific research and technological innovation, this approach is misguided and...  View Details
Keywords: Big Data; Science-based; Science; Scientific Research; Data Analytics; Data Science; Data-driven Management; Data Scientists; Technological Innovation; Data and Data Sets; Mathematical Methods; Theory
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  • October 2016 (Revised September 2017)
  • Case

The CRISPR-Cas9 Quarrel
By: Richard G. Hamermesh and Matthew G. Preble
In mid-2016, the Broad Institute and the University of California, Berkeley were in the middle of a contentious patent dispute over which entity controlled a breakthrough gene editing technology called CRISPR-Cas9. With CRISPR-Cas9, scientists might soon be able to...  View Details
Keywords: CRISPR; Broad Institute; University Of California Berkeley; Intellectual Property; Patents; Law; Lawsuits and Litigation; Science; Genetics; Entrepreneurship; Biotechnology Industry; United States
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  • October 2016
  • Article

Looking Across and Looking Beyond the Knowledge Frontier: Intellectual Distance and Resource Allocation in Science
By: Kevin J. Boudreau, Eva Guinan, Karim R. Lakhani and Christoph Riedl
Selecting among alternative innovative projects is a core management task in all innovating organizations. In this paper, we focus on the evaluation of frontier scientific research projects. We argue that the "intellectual distance" between the knowledge embodied in...  View Details
Keywords: Knowledge; Innovation; Novelty; Evaluation; Resource Allocation; Decision Choices and Conditions; Innovation and Management; Science-Based Business; Experience and Expertise
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  • February 2016
  • Article

Bridging Science and Technology Through Academic-Industry Partnerships
By: Sen Chai and Willy C. Shih
Partnerships that foster the translation of scientific advances emerging from academic research organizations into commercialized products at private firms are a policy tool that has attracted increased interest. This paper examines empirical data from the Danish...  View Details
Keywords: Economic Development; Technological Change; Government Policy; Technological Innovation; Research and Development; Technology; Policy; Technology Industry; Denmark
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  • November 2014
  • Case

Napalm: From Soldiers Field to Trang Bang
By: Tom Nicholas and Jonas Peter Akins
Napalm is one of the most destructive weapons ever to be invented. Yet, at its original inception it was nothing more than a technical challenge, and it was never intended to be used in indiscriminate antipersonnel warfare. The pathway of its development by a Harvard...  View Details
Keywords: Moral Sensibility; War; Chemicals; Research and Development; Chemical Industry; Viet Nam; Cambridge; United States
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  • September 2013
  • Article

Prizes, Publicity, and Patents: Non-Monetary Awards as a Mechanism to Encourage Innovation
By: Petra Moser and Tom Nicholas
This paper exploits the selection of prize-winning technologies among exhibitors at the Crystal Palace Exhibition in 1851 to examine whether—and how—ex post prizes that are awarded to high-quality innovations may encourage future innovation. U.S. patent data...  View Details
Keywords: Prizes; Innovation; Motivation and Incentives; Patents; Innovation and Invention
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  • 2013
  • Book

Happy Money: The Science of Happier Spending
By: Elizabeth Dunn and Michael Norton
If you think money can't buy happiness, you're not spending it right. Two rising stars in behavioral science explain how money can buy happiness—if you follow five core principles of smarter spending. Happy Money offers a tour of new research on the science of...  View Details
Keywords: Happiness; Spending; Personal Finance
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