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- 2023
- Working Paper
Won’t You Be My Neighbor? Events, Knowledge Spillovers, and Entrepreneur Performance in Togo
By: Stefan Dimitiadis and Rembrand Koning
Spatial proximity between firms plays a crucial role in entrepreneurship by creating knowledge spillovers, enabling resource sharing, and sparking productivity gains. Building on these insights, research has explored whether institutions and organizations can engineer...
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Dimitiadis, Stefan, and Rembrand Koning. "Won’t You Be My Neighbor? Events, Knowledge Spillovers, and Entrepreneur Performance in Togo." Working Paper, February 2023.
- January 2023
- Case
Cleave Therapeutics: Taking a Risk on Oncology Drug Discovery
By: Regina Herzlinger and Brian Walker
How can a successful executive assess her next move as the CEO of a firm with a promising and yet uncertain new drug? Amy Burroughs’ mandate to find a therapeutic window for Cleave Therapeutics oncology drug was on track but faced an uncertain future. Overseeing the...
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- 2022
- Working Paper
Regulatory Incentives for Innovation: The FDA's Breakthrough Therapy Designation
By: Amitabh Chandra, Jennifer Kao, Kathleen Miller and Ariel D. Stern
Regulators of new products confront a tradeoff between speeding a new product to market and collecting additional product quality information. The FDA’s Breakthrough Therapy Designation (BTD) provides an opportunity to understand if a regulator can use new policy to...
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Chandra, Amitabh, Jennifer Kao, Kathleen Miller, and Ariel D. Stern. "Regulatory Incentives for Innovation: The FDA's Breakthrough Therapy Designation." NBER Working Paper Series, No. 30712, December 2022.
- December 2022
- Article
When and How Should Firms Differentiate? Quality and Advertising Decisions in a Duopoly
By: Dominique Olié Lauga, Elie Ofek and Zsolt Katona
A prominent hallmark of competitive interaction is the desire to differentiate from rivals. In this article, the authors examine under what conditions firms will differentiate through product quality versus advertising intensity. Firms select quality in a first stage,...
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Lauga, Dominique Olié, Elie Ofek, and Zsolt Katona. "When and How Should Firms Differentiate? Quality and Advertising Decisions in a Duopoly." Journal of Marketing Research (JMR) 59, no. 2 (December 2022): 1252–1265.
- November 2022 (Revised December 2022)
- Case
Replika AI: Monetizing a Chatbot
By: Julian De Freitas and Nicole Tempest Keller
In early 2018, Eugenia Kuyda, co-founder and CEO of San Francisco-based chatbot Replika AI, was deciding how to monetize the app she had built. Launched in 2017, Replika was a consumer AI “companion app” developed by a team of AI software engineers originally based in...
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Keywords:
Mental Health;
Subscriber Models;
TAM;
Monetization Strategy;
Marketing Strategy;
Product Marketing;
AI and Machine Learning;
Applications and Software;
Product Positioning;
Health Disorders;
Technology Industry
De Freitas, Julian, and Nicole Tempest Keller. "Replika AI: Monetizing a Chatbot." Harvard Business School Case 523-016, November 2022. (Revised December 2022.)
- November 2022 (Revised January 2023)
- Case
Hugging Face: Serving AI on a Platform
By: Shane Greenstein, Daniel Yue, Kerry Herman and Sarah Gulick
It is fall 2022, and open-source AI model company Hugging Face is considering its three areas of priorities: platform development, supporting the open-source community, and pursuing cutting-edge scientific research. As it expands services for enterprise clients, which...
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Keywords:
Community;
Open-source;
AI and Machine Learning;
Product Development;
Networks;
Service Delivery;
Research;
Governance;
Business and Stakeholder Relations;
Information Industry;
Technology Industry;
United States
Greenstein, Shane, Daniel Yue, Kerry Herman, and Sarah Gulick. "Hugging Face: Serving AI on a Platform." Harvard Business School Case 623-026, November 2022. (Revised January 2023.)
- 2022
- Book
Healthy Buildings: How Indoor Spaces Can Make You Sick—or Keep You Well
By: Joseph G. Allen and John D. Macomber
For too long we’ve designed buildings that haven’t focused on the people inside—their health, their ability to work effectively, and what that means for the bottom line. An authoritative introduction to a movement whose vital importance is now all too clear, Healthy...
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Allen, Joseph G., and John D. Macomber. Healthy Buildings: How Indoor Spaces Can Make You Sick—or Keep You Well. Revised and updated edition, Cambridge, MA: Harvard University Press, 2022.
- September 2022
- Case
Proactive for Her
By: Rembrand Koning and Kairavi Dey
Proactive for Her began amid the COVID-19 pandemic, in August 2020 as a digital platform to provide accessible, evidence-based, primary, preventive non-judgmental healthcare services for Indian women, who were often dissuaded from seeking help as premarital sex and...
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Keywords:
Women's Health;
Healthcare;
India;
Start-up;
Telehealth;
Digital Platforms;
Health Care and Treatment;
Customer Focus and Relationships;
Business Startups;
Health Industry;
Asia;
South Asia;
India
Koning, Rembrand, and Kairavi Dey. "Proactive for Her." Harvard Business School Case 723-351, September 2022.
- September 2022
- Article
Find and Replace: R&D Investment Following the Erosion of Existing Products
By: Joshua L. Krieger, Xuelin Li and Richard T. Thakor
How do innovative firms react when existing products experience negative shocks? We explore this question with detailed project-level data from drug development firms. Using FDA Public Health Advisories as idiosyncratic negative shocks to approved drugs, we first...
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Keywords:
R&D Investments;
Drug Development;
Product Shocks;
M&A;
Biopharmaceutical Industry;
FDA;
System Shocks;
Research and Development;
Investment;
Decision Making;
Pharmaceutical Industry
Krieger, Joshua L., Xuelin Li, and Richard T. Thakor. "Find and Replace: R&D Investment Following the Erosion of Existing Products." Management Science 68, no. 9 (September 2022): 6552–6571.
- August 2022
- Exercise
Joy4Home Brands: Pricing Matters
By: Elie Ofek, Oded Koenigsberg and Marco Bertini
Joy4Home Brands, the maker of novel houseware items, was gearing up for its launch. The company would be introducing two lines: kitchenware products and storage containers. The initial go-to-market plan called for a direct to consumer (DTC) channel strategy. While...
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Keywords:
DTC;
Pricing Decisions;
B2B;
Product Marketing;
Product Launch;
Marketing Strategy;
Business Model;
Opportunities;
Consumer Products Industry
Ofek, Elie, Oded Koenigsberg, and Marco Bertini. "Joy4Home Brands: Pricing Matters." Harvard Business School Exercise 523-709, August 2022.
- June 29, 2022
- Other Article
Strategic Complexity? Using Experiments to Understand and Overcome Obfuscation
By: Michael Luca, Ginger Zhe Jin and Daniel Martin
Credit card companies must decide what product features to disclose to consumers, such as payment schedules, penalties, and fees--and also whether to present them clearly or bury them in the fine print. Firms face similar choices in settings ranging from privacy...
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Keywords:
Obfuscation;
Credit Cards;
Strategic Incentives;
Complexity;
Agreements and Arrangements;
Customers;
Consumer Behavior;
Financial Services Industry
Luca, Michael, Ginger Zhe Jin, and Daniel Martin. "Strategic Complexity? Using Experiments to Understand and Overcome Obfuscation." Management Science Review (June 29, 2022). (Summary of "Complex Disclosure," Management Science, May 2022.)
- 2022
- Working Paper
Innovation on Wings: Nonstop Flights and Firm Innovation in the Global Context
By: Dany Bahar, Prithwiraj Choudhury, Do Yoon Kim and Wesley W. Koo
We study whether, when, and how better connectivity through nonstop flights leads to positive innovation outcomes for firms in the global context. Using unique data of all flights emanating from 5,015 airports around the globe from 2005 to 2015 and exploiting a...
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Keywords:
Nonstop Flights;
Collaborative Innovation and Invention;
Patents;
Research and Development;
Air Transportation Industry
Bahar, Dany, Prithwiraj Choudhury, Do Yoon Kim, and Wesley W. Koo. "Innovation on Wings: Nonstop Flights and Firm Innovation in the Global Context." Harvard Business School Working Paper, No. 23-009, July 2022.
- Article
Online Experimentation: Benefits, Operational and Methodological Challenges, and Scaling Guide
By: Iavor Bojinov and Somit Gupta
In the past decade, online controlled experimentation, or A/B testing, at scale has proved to be a significant driver of business innovation. The practice was first pioneered by the technology sector and, more recently, has been adopted by traditional companies...
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Keywords:
A/B Testing;
Experimentation;
Data-driven Culture;
Product Development;
Innovation and Invention;
Digital Transformation
Bojinov, Iavor, and Somit Gupta. "Online Experimentation: Benefits, Operational and Methodological Challenges, and Scaling Guide." Harvard Data Science Review, no. 4.3 (Summer, 2022).
- 2022
- Working Paper
Laboratory Safety and Research Productivity
By: Alberto Galasso, Hong Luo and Brooklynn Zhu
Are laboratory safety practices a tax on scientific productivity? We examine this question by exploiting the substantial increase in safety regulations at the University of California following the shocking accidental death of a research assistant in 2008....
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Keywords:
Economics Of Science;
Risk Perception;
Safety Regulations;
Safety;
Working Conditions;
Governing Rules, Regulations, and Reforms;
Innovation and Invention
Galasso, Alberto, Hong Luo, and Brooklynn Zhu. "Laboratory Safety and Research Productivity." Harvard Business School Working Paper, No. 22-072, May 2022.
- 2022
- Book
Productive Tensions: How Every Leader Can Tackle Innovation's Toughest Trade-Offs
By: Chris Bingham and Rory McDonald
Why is leading innovation in nascent business environments so distressingly hit-or-miss? More than 90% of high-potential ventures don’t reach their projected targets. Surveys show that 80% of executives consider innovation crucial to their growth strategy, but only 6%...
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Keywords:
Growth and Development Strategy;
Innovation and Management;
Organizational Culture;
Leadership Style;
Decision Making
Bingham, Chris, and Rory McDonald. Productive Tensions: How Every Leader Can Tackle Innovation's Toughest Trade-Offs. Cambridge, MA: MIT Press, 2022.
- March 2022
- Module Note
Navigating Nascent Industries and Product Categories
By: Rory McDonald
This Note introduces a module of cases used at Harvard Business School to teach fundamental concepts about navigating nascent industries and product categories. It elaborates a set of ‘innovation tensions’ that managers must address in these domains. In connecting the...
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McDonald, Rory. "Navigating Nascent Industries and Product Categories." Harvard Business School Module Note 622-097, March 2022.
- Article
Eliminating Unintended Bias in Personalized Policies Using Bias-Eliminating Adapted Trees (BEAT)
By: Eva Ascarza and Ayelet Israeli
An inherent risk of algorithmic personalization is disproportionate targeting of individuals from certain groups (or demographic characteristics such as gender or race), even when the decision maker does not intend to discriminate based on those “protected”... View Details
Keywords:
Algorithm Bias;
Personalization;
Targeting;
Generalized Random Forests (GRF);
Discrimination;
Customization and Personalization;
Decision Making;
Fairness;
Mathematical Methods
Ascarza, Eva, and Ayelet Israeli. "Eliminating Unintended Bias in Personalized Policies Using Bias-Eliminating Adapted Trees (BEAT)." e2115126119. Proceedings of the National Academy of Sciences 119, no. 11 (March 8, 2022).
- Article
Advancing Digital Health Applications: Priorities for Innovation in Real-World Evidence Generation
By: Ariel Dora Stern, Jan Brönneke, Jörg F Debatin, Julia Hagen, Henrik Matthies, Smit Patel, Ieuan Clay, Bjoern Eskofier, Annika Herr, Kurt Hoeller, Ashley Jaksa, Daniel B Kramer, Mattias Kyhlstedt, Katherine T Lofgren, Nirosha Mahendraratnam, Holger Muehlan, Simon Reif, Lars Riedemann and Jennifer C Goldsack
In 2019, Germany passed the Digital Healthcare Act, which, among other things, created a “Fast-Track” regulatory and reimbursement pathway for digital health applications in the German market. The pathway explicitly provides for flexibility in how researchers can...
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Stern, Ariel Dora, Jan Brönneke, Jörg F Debatin, Julia Hagen, Henrik Matthies, Smit Patel, Ieuan Clay, Bjoern Eskofier, Annika Herr, Kurt Hoeller, Ashley Jaksa, Daniel B Kramer, Mattias Kyhlstedt, Katherine T Lofgren, Nirosha Mahendraratnam, Holger Muehlan, Simon Reif, Lars Riedemann, and Jennifer C Goldsack. "Advancing Digital Health Applications: Priorities for Innovation in Real-World Evidence Generation." Lancet Digital Health 4, no. 3 (March 2022): e200–e206.
- March 2022
- Article
Estimating the Effectiveness of Permanent Price Reductions for Competing Products Using Multivariate Bayesian Structural Time Series Models
By: Fiammetta Menchetti and Iavor Bojinov
Researchers regularly use synthetic control methods for estimating causal effects when a sub-set of units receive a single persistent treatment, and the rest are unaffected by the change. In many applications, however, units not assigned to treatment are nevertheless...
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Keywords:
Causal Inference;
Partial Interference;
Synthetic Controls;
Bayesian Structural Time Series;
Mathematical Methods
Menchetti, Fiammetta, and Iavor Bojinov. "Estimating the Effectiveness of Permanent Price Reductions for Competing Products Using Multivariate Bayesian Structural Time Series Models." Annals of Applied Statistics 16, no. 1 (March 2022): 414–435.
- February 2022 (Revised September 2022)
- Case
InstaDeep: AI Innovation Born in Africa (A)
By: Shikhar Ghosh and Esel Çekin
Karim Beguir and Zohra Slim were the co-founders of InstaDeep, a deep tech startup focusing on artificial intelligence (AI) solutions. Instadeep was one of the few companies globally that were partnering with DeepMind, an AI subsidiary of Google [Alphabet Inc.]....
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Keywords:
AI;
Artificial Intelligence;
Entrepreneurship;
Operations;
Business Subsidiaries;
Brands and Branding;
Innovation and Invention;
Growth and Development Strategy;
AI and Machine Learning;
Technology Industry;
Africa
Ghosh, Shikhar, and Esel Çekin. "InstaDeep: AI Innovation Born in Africa (A)." Harvard Business School Case 822-104, February 2022. (Revised September 2022.)