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      • Faculty Publications  (519)

      Research Productivity Remove Research Productivity →

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      • 2023
      • Working Paper

      Won’t You Be My Neighbor? Events, Knowledge Spillovers, and Entrepreneur Performance in Togo

      By: Stefan Dimitiadis and Rembrand Koning
      Spatial proximity between firms plays a crucial role in entrepreneurship by creating knowledge spillovers, enabling resource sharing, and sparking productivity gains. Building on these insights, research has explored whether institutions and organizations can engineer...  View Details
      Keywords: Local Range; Knowledge Sharing; Performance Productivity; Togo
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      Dimitiadis, Stefan, and Rembrand Koning. "Won’t You Be My Neighbor? Events, Knowledge Spillovers, and Entrepreneur Performance in Togo." Working Paper, February 2023.
      • January 2023
      • Case

      Cleave Therapeutics: Taking a Risk on Oncology Drug Discovery

      By: Regina Herzlinger and Brian Walker
      How can a successful executive assess her next move as the CEO of a firm with a promising and yet uncertain new drug? Amy Burroughs’ mandate to find a therapeutic window for Cleave Therapeutics oncology drug was on track but faced an uncertain future. Overseeing the...  View Details
      Keywords: Product Development; Leadership; Health Testing and Trials; Research and Development; Risk and Uncertainty; Financial Condition; Partners and Partnerships; Pharmaceutical Industry
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      Herzlinger, Regina, and Brian Walker. "Cleave Therapeutics: Taking a Risk on Oncology Drug Discovery." Harvard Business School Case 323-045, January 2023.
      • 2022
      • Working Paper

      Regulatory Incentives for Innovation: The FDA's Breakthrough Therapy Designation

      By: Amitabh Chandra, Jennifer Kao, Kathleen Miller and Ariel D. Stern
      Regulators of new products confront a tradeoff between speeding a new product to market and collecting additional product quality information. The FDA’s Breakthrough Therapy Designation (BTD) provides an opportunity to understand if a regulator can use new policy to...  View Details
      Keywords: Research and Development; Governing Rules, Regulations, and Reforms; Product Development
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      Chandra, Amitabh, Jennifer Kao, Kathleen Miller, and Ariel D. Stern. "Regulatory Incentives for Innovation: The FDA's Breakthrough Therapy Designation." NBER Working Paper Series, No. 30712, December 2022.
      • December 2022
      • Article

      When and How Should Firms Differentiate? Quality and Advertising Decisions in a Duopoly

      By: Dominique Olié Lauga, Elie Ofek and Zsolt Katona
      A prominent hallmark of competitive interaction is the desire to differentiate from rivals. In this article, the authors examine under what conditions firms will differentiate through product quality versus advertising intensity. Firms select quality in a first stage,...  View Details
      Keywords: Competition; Advertising; Product Positioning
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      Lauga, Dominique Olié, Elie Ofek, and Zsolt Katona. "When and How Should Firms Differentiate? Quality and Advertising Decisions in a Duopoly." Journal of Marketing Research (JMR) 59, no. 2 (December 2022): 1252–1265.
      • November 2022 (Revised December 2022)
      • Case

      Replika AI: Monetizing a Chatbot

      By: Julian De Freitas and Nicole Tempest Keller
      In early 2018, Eugenia Kuyda, co-founder and CEO of San Francisco-based chatbot Replika AI, was deciding how to monetize the app she had built. Launched in 2017, Replika was a consumer AI “companion app” developed by a team of AI software engineers originally based in...  View Details
      Keywords: Mental Health; Subscriber Models; TAM; Monetization Strategy; Marketing Strategy; Product Marketing; AI and Machine Learning; Applications and Software; Product Positioning; Health Disorders; Technology Industry
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      De Freitas, Julian, and Nicole Tempest Keller. "Replika AI: Monetizing a Chatbot." Harvard Business School Case 523-016, November 2022. (Revised December 2022.)
      • November 2022 (Revised January 2023)
      • Case

      Hugging Face: Serving AI on a Platform

      By: Shane Greenstein, Daniel Yue, Kerry Herman and Sarah Gulick
      It is fall 2022, and open-source AI model company Hugging Face is considering its three areas of priorities: platform development, supporting the open-source community, and pursuing cutting-edge scientific research. As it expands services for enterprise clients, which...  View Details
      Keywords: Community; Open-source; AI and Machine Learning; Product Development; Networks; Service Delivery; Research; Governance; Business and Stakeholder Relations; Information Industry; Technology Industry; United States
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      Greenstein, Shane, Daniel Yue, Kerry Herman, and Sarah Gulick. "Hugging Face: Serving AI on a Platform." Harvard Business School Case 623-026, November 2022. (Revised January 2023.)
      • 2022
      • Book

      Healthy Buildings: How Indoor Spaces Can Make You Sick—or Keep You Well

      By: Joseph G. Allen and John D. Macomber
      For too long we’ve designed buildings that haven’t focused on the people inside—their health, their ability to work effectively, and what that means for the bottom line. An authoritative introduction to a movement whose vital importance is now all too clear, Healthy...  View Details
      Keywords: COVID-19; Buildings and Facilities; Health; Health Pandemics; Safety
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      Allen, Joseph G., and John D. Macomber. Healthy Buildings: How Indoor Spaces Can Make You Sick—or Keep You Well. Revised and updated edition, Cambridge, MA: Harvard University Press, 2022.
      • September 2022
      • Case

      Proactive for Her

      By: Rembrand Koning and Kairavi Dey
      Proactive for Her began amid the COVID-19 pandemic, in August 2020 as a digital platform to provide accessible, evidence-based, primary, preventive non-judgmental healthcare services for Indian women, who were often dissuaded from seeking help as premarital sex and...  View Details
      Keywords: Women's Health; Healthcare; India; Start-up; Telehealth; Digital Platforms; Health Care and Treatment; Customer Focus and Relationships; Business Startups; Health Industry; Asia; South Asia; India
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      Koning, Rembrand, and Kairavi Dey. "Proactive for Her." Harvard Business School Case 723-351, September 2022.
      • September 2022
      • Article

      Find and Replace: R&D Investment Following the Erosion of Existing Products

      By: Joshua L. Krieger, Xuelin Li and Richard T. Thakor
      How do innovative firms react when existing products experience negative shocks? We explore this question with detailed project-level data from drug development firms. Using FDA Public Health Advisories as idiosyncratic negative shocks to approved drugs, we first...  View Details
      Keywords: R&D Investments; Drug Development; Product Shocks; M&A; Biopharmaceutical Industry; FDA; System Shocks; Research and Development; Investment; Decision Making; Pharmaceutical Industry
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      Krieger, Joshua L., Xuelin Li, and Richard T. Thakor. "Find and Replace: R&D Investment Following the Erosion of Existing Products." Management Science 68, no. 9 (September 2022): 6552–6571.
      • August 2022
      • Exercise

      Joy4Home Brands: Pricing Matters

      By: Elie Ofek, Oded Koenigsberg and Marco Bertini
      Joy4Home Brands, the maker of novel houseware items, was gearing up for its launch. The company would be introducing two lines: kitchenware products and storage containers. The initial go-to-market plan called for a direct to consumer (DTC) channel strategy. While...  View Details
      Keywords: DTC; Pricing Decisions; B2B; Product Marketing; Product Launch; Marketing Strategy; Business Model; Opportunities; Consumer Products Industry
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      Ofek, Elie, Oded Koenigsberg, and Marco Bertini. "Joy4Home Brands: Pricing Matters." Harvard Business School Exercise 523-709, August 2022.
      • June 29, 2022
      • Other Article

      Strategic Complexity? Using Experiments to Understand and Overcome Obfuscation

      By: Michael Luca, Ginger Zhe Jin and Daniel Martin
      Credit card companies must decide what product features to disclose to consumers, such as payment schedules, penalties, and fees--and also whether to present them clearly or bury them in the fine print. Firms face similar choices in settings ranging from privacy...  View Details
      Keywords: Obfuscation; Credit Cards; Strategic Incentives; Complexity; Agreements and Arrangements; Customers; Consumer Behavior; Financial Services Industry
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      Luca, Michael, Ginger Zhe Jin, and Daniel Martin. "Strategic Complexity? Using Experiments to Understand and Overcome Obfuscation." Management Science Review (June 29, 2022). (Summary of "Complex Disclosure," Management Science, May 2022.)
      • 2022
      • Working Paper

      Innovation on Wings: Nonstop Flights and Firm Innovation in the Global Context

      By: Dany Bahar, Prithwiraj Choudhury, Do Yoon Kim and Wesley W. Koo
      We study whether, when, and how better connectivity through nonstop flights leads to positive innovation outcomes for firms in the global context. Using unique data of all flights emanating from 5,015 airports around the globe from 2005 to 2015 and exploiting a...  View Details
      Keywords: Nonstop Flights; Collaborative Innovation and Invention; Patents; Research and Development; Air Transportation Industry
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      Bahar, Dany, Prithwiraj Choudhury, Do Yoon Kim, and Wesley W. Koo. "Innovation on Wings: Nonstop Flights and Firm Innovation in the Global Context." Harvard Business School Working Paper, No. 23-009, July 2022.
      • Article

      Online Experimentation: Benefits, Operational and Methodological Challenges, and Scaling Guide

      By: Iavor Bojinov and Somit Gupta
      In the past decade, online controlled experimentation, or A/B testing, at scale has proved to be a significant driver of business innovation. The practice was first pioneered by the technology sector and, more recently, has been adopted by traditional companies...  View Details
      Keywords: A/B Testing; Experimentation; Data-driven Culture; Product Development; Innovation and Invention; Digital Transformation
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      Bojinov, Iavor, and Somit Gupta. "Online Experimentation: Benefits, Operational and Methodological Challenges, and Scaling Guide." Harvard Data Science Review, no. 4.3 (Summer, 2022).
      • 2022
      • Working Paper

      Laboratory Safety and Research Productivity

      By: Alberto Galasso, Hong Luo and Brooklynn Zhu
      Are laboratory safety practices a tax on scientific productivity? We examine this question by exploiting the substantial increase in safety regulations at the University of California following the shocking accidental death of a research assistant in 2008....  View Details
      Keywords: Economics Of Science; Risk Perception; Safety Regulations; Safety; Working Conditions; Governing Rules, Regulations, and Reforms; Innovation and Invention
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      Galasso, Alberto, Hong Luo, and Brooklynn Zhu. "Laboratory Safety and Research Productivity." Harvard Business School Working Paper, No. 22-072, May 2022.
      • 2022
      • Book

      Productive Tensions: How Every Leader Can Tackle Innovation's Toughest Trade-Offs

      By: Chris Bingham and Rory McDonald
      Why is leading innovation in nascent business environments so distressingly hit-or-miss? More than 90% of high-potential ventures don’t reach their projected targets. Surveys show that 80% of executives consider innovation crucial to their growth strategy, but only 6%...  View Details
      Keywords: Growth and Development Strategy; Innovation and Management; Organizational Culture; Leadership Style; Decision Making
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      Bingham, Chris, and Rory McDonald. Productive Tensions: How Every Leader Can Tackle Innovation's Toughest Trade-Offs. Cambridge, MA: MIT Press, 2022.
      • March 2022
      • Module Note

      Navigating Nascent Industries and Product Categories

      By: Rory McDonald
      This Note introduces a module of cases used at Harvard Business School to teach fundamental concepts about navigating nascent industries and product categories. It elaborates a set of ‘innovation tensions’ that managers must address in these domains. In connecting the...  View Details
      Keywords: Nascent Industries; Product; Innovation and Management; Strategy
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      McDonald, Rory. "Navigating Nascent Industries and Product Categories." Harvard Business School Module Note 622-097, March 2022.
      • Article

      Eliminating Unintended Bias in Personalized Policies Using Bias-Eliminating Adapted Trees (BEAT)

      By: Eva Ascarza and Ayelet Israeli

      An inherent risk of algorithmic personalization is disproportionate targeting of individuals from certain groups (or demographic characteristics such as gender or race), even when the decision maker does not intend to discriminate based on those “protected”...  View Details

      Keywords: Algorithm Bias; Personalization; Targeting; Generalized Random Forests (GRF); Discrimination; Customization and Personalization; Decision Making; Fairness; Mathematical Methods
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      Ascarza, Eva, and Ayelet Israeli. "Eliminating Unintended Bias in Personalized Policies Using Bias-Eliminating Adapted Trees (BEAT)." e2115126119. Proceedings of the National Academy of Sciences 119, no. 11 (March 8, 2022).
      • Article

      Advancing Digital Health Applications: Priorities for Innovation in Real-World Evidence Generation

      By: Ariel Dora Stern, Jan Brönneke, Jörg F Debatin, Julia Hagen, Henrik Matthies, Smit Patel, Ieuan Clay, Bjoern Eskofier, Annika Herr, Kurt Hoeller, Ashley Jaksa, Daniel B Kramer, Mattias Kyhlstedt, Katherine T Lofgren, Nirosha Mahendraratnam, Holger Muehlan, Simon Reif, Lars Riedemann and Jennifer C Goldsack
      In 2019, Germany passed the Digital Healthcare Act, which, among other things, created a “Fast-Track” regulatory and reimbursement pathway for digital health applications in the German market. The pathway explicitly provides for flexibility in how researchers can...  View Details
      Keywords: Digital Health; Health Care and Treatment; Technological Innovation
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      Stern, Ariel Dora, Jan Brönneke, Jörg F Debatin, Julia Hagen, Henrik Matthies, Smit Patel, Ieuan Clay, Bjoern Eskofier, Annika Herr, Kurt Hoeller, Ashley Jaksa, Daniel B Kramer, Mattias Kyhlstedt, Katherine T Lofgren, Nirosha Mahendraratnam, Holger Muehlan, Simon Reif, Lars Riedemann, and Jennifer C Goldsack. "Advancing Digital Health Applications: Priorities for Innovation in Real-World Evidence Generation." Lancet Digital Health 4, no. 3 (March 2022): e200–e206.
      • March 2022
      • Article

      Estimating the Effectiveness of Permanent Price Reductions for Competing Products Using Multivariate Bayesian Structural Time Series Models

      By: Fiammetta Menchetti and Iavor Bojinov
      Researchers regularly use synthetic control methods for estimating causal effects when a sub-set of units receive a single persistent treatment, and the rest are unaffected by the change. In many applications, however, units not assigned to treatment are nevertheless...  View Details
      Keywords: Causal Inference; Partial Interference; Synthetic Controls; Bayesian Structural Time Series; Mathematical Methods
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      Menchetti, Fiammetta, and Iavor Bojinov. "Estimating the Effectiveness of Permanent Price Reductions for Competing Products Using Multivariate Bayesian Structural Time Series Models." Annals of Applied Statistics 16, no. 1 (March 2022): 414–435.
      • February 2022 (Revised September 2022)
      • Case

      InstaDeep: AI Innovation Born in Africa (A)

      By: Shikhar Ghosh and Esel Çekin
      Karim Beguir and Zohra Slim were the co-founders of InstaDeep, a deep tech startup focusing on artificial intelligence (AI) solutions. Instadeep was one of the few companies globally that were partnering with DeepMind, an AI subsidiary of Google [Alphabet Inc.]....  View Details
      Keywords: AI; Artificial Intelligence; Entrepreneurship; Operations; Business Subsidiaries; Brands and Branding; Innovation and Invention; Growth and Development Strategy; AI and Machine Learning; Technology Industry; Africa
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      Ghosh, Shikhar, and Esel Çekin. "InstaDeep: AI Innovation Born in Africa (A)." Harvard Business School Case 822-104, February 2022. (Revised September 2022.)
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