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- October 2023
- Case
Fixie and Conversational AI Sidekicks
By: Jeffrey J. Bussgang and Carin-Isabel Knoop
In March 2023, Fixie Co-Founder and Chief Architect Matt Welsh and co-founders had the kind of meeting no founders want to have. The president of leading artificial intelligence (AI) research and deployment firm OpenAI, which had catapulted into fame with its ChatGPT...
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- 2023
- Working Paper
Causal Interpretation of Structural IV Estimands
By: Isaiah Andrews, Nano Barahona, Matthew Gentzkow, Ashesh Rambachan and Jesse M. Shapiro
We study the causal interpretation of instrumental variables (IV) estimands of nonlinear, multivariate structural models with respect to rich forms of model misspecification. We focus on guaranteeing that the researcher's estimator is sharp zero consistent, meaning...
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Keywords:
Mathematical Methods
- October 2023
- Article
Innovation on Wings: When Do Nonstop Flights Matter for Global Innovation?
By: Dany Bahar, Prithwiraj Choudhury, Do Yoon Kim and Wesley Koo
We study whether, when, and how better connectivity through nonstop flights leads to positive innovation outcomes for firms in the global context. Using unique data of all flights emanating from 5,015 airports around the globe from 2005 to 2015 and exploiting a...
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- October 2023
- Article
Laboratory Safety and Research Productivity
By: Alberto Galasso, Hong Luo and Brooklynn Zhu
Are laboratory safety practices a tax on scientific productivity? We examine this question by exploiting the substantial increase in safety regulations at the University of California following the shocking accidental death of a research assistant in 2008....
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- September 2023 (Revised September 2023)
- Case
RightHand Robotics: Choosing the First Market
By: Thomas R. Eisenmann and Stacy Straaberg
In early 2015, RightHand Robotics’s (RHR) leadership faced several decisions in commercializing the startup’s robotic picking solution. RHR’s central product was the RightPick integrated robotic picking system which featured a robotic arm, a three-fingered robotic hand...
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- July 2023
- Case
DayTwo: Going to Market with Gut Microbiome (Abridged)
By: Ayelet Israeli
DayTwo is a young Israeli startup that applies research on the gut microbiome and machine learning algorithms to deliver personalized nutritional recommendations to its users in order to minimize blood sugar spikes after meals. After a first year of trial rollout in...
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- 18 Jul 2023
- Interview
Jeffrey Rayport on Product Market Fit, Profit Market Fit and Whiplash, and More
By: Jeffrey F. Rayport and Doug Levin
This episode of "Lessons from Startup Life" podcast features Jeffrey Rayport, Senior Lecturer of Business Administration at the Harvard Business School. Jeffrey specializes in teaching and researching growth-stage technology ventures and their scalability. Prior to...
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- June 2023
- Case
Investing in the Climate Transition at Neuberger Berman
By: George Serafeim and Benjamin Maletta
By mid-2023, Neuberger Berman (NB), an active asset manager, had grown its assets under management to about half a trillion dollars and took pride in its client centricity and innovative spirit. Responding to client demand for investment products that integrated...
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Keywords:
Carbon Emissions;
Sustainability;
Decarbonization;
Performance;
Risk Assessment;
Opportunities;
Environmental Sustainability;
Carbon Footprint;
Business Analysis;
Investing;
Regulation;
Asset Management;
Investment Strategy;
Climate Change;
Transition;
Analysis;
Product Positioning;
Strategy;
Investment Portfolio;
Financial Services Industry;
Energy Industry
- 2023
- Working Paper
Design-Based Confidence Sequences: A General Approach to Risk Mitigation in Online Experimentation
By: Dae Woong Ham, Michael Lindon, Martin Tingley and Iavor Bojinov
Randomized experiments have become the standard method for companies to evaluate the performance of new products or services. In addition to augmenting managers’ decision-making, experimentation mitigates risk by limiting the proportion of customers exposed to...
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- June 2023
- Case
Verve Therapeutics: Taking DNA Editing to Heart
By: Shikhar Ghosh and Shweta Bagai
Verve Therapeutics, a public biotech company based in Boston, created a novel approach to addressing cardiovascular disease (CVD) - a leading cause of deaths globally. The company's approach was a single shot treatment to permanently lower cholesterol, thus reducing...
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- May 2023 (Revised June 2023)
- Supplement
Novartis (B): Reimagining Medicine
By: Ramon Casadesus-Masanell, Claudio Feser, Karolin Frankenberger and David Redaschi
This case unfolds around the first-ever approved personalized cancer treatment, how Novartis wrapped it into a new business model design, and how Novartis scaled it. Novartis — one of the largest pharmaceutical companies in the world — is, among other ventures,...
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- 2023
- Book
Research Handbook on Digital Strategy
By: Carmelo Cennamo, Giovanni Battista Dagnino and Feng Zhu
This state-of-the-art Research Handbook presents a comprehensive overview of the key strategic challenges that firms face when dealing with digital markets, platforms, and products and services, from old strategy questions in need of different solutions to entirely...
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Keywords:
Digital Strategy
- 2023
- Working Paper
Using GPT for Market Research
By: James Brand, Ayelet Israeli and Donald Ngwe
Large language models (LLMs) have quickly become popular as labor-augmenting tools
for programming, writing, and many other processes that benefit from quick text generation.
In this paper we explore the uses and benefits of LLMs for researchers and...
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- April 2023 (Revised November 2023)
- Case
AI Wars
By: Andy Wu, Matt Higgins, Miaomiao Zhang and Hang Jiang
In November 2023, the world was looking to Google to see what the search giant and long-time putative technical leader in artificial intelligence (AI) would do to compete in the massively hyped technology of generative AI. Just a year ago, OpenAI released ChatGPT, a...
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- April 2023 (Revised September 2023)
- Case
Levels: The Remote, Asynchronous, Deep Work Management System
By: Joseph B. Fuller and George Gonzalez
Levels is a highly innovative startup in the health care space. They intend to revolutionize health by linking behavior—eating, exercise, sleeping, etc.—to changes in metabolism. They believe metabolic health can be managed through careful monitoring of changes in...
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- March 31, 2023
- Article
What Is the Optimal Pattern of a Customer Journey?
Even though customer experience (CX) leaders are becoming increasingly focused on optimizing their firms’ customer journeys, they face a clear challenge: Which touchpoints along the journey should they invest in? That is, which moments when the customer interacts with...
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- March, 2023
- Article
Academic Entrepreneurship: Entrepreneurial Advisors and Their Advisees' Outcomes
By: Maria P. Roche
The transfer of complex knowledge and skills is difficult, often requiring intensive interaction and extensive periods of co-working between a mentor and mentee, which is particularly true in apprenticeship-like settings and on-the-job training. This paper studies a...
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- February 2023
- Article
Climate Solutions Investments
By: Alex Cheema-Fox, George Serafeim and Hui (Stacie) Wang
An increasing number of companies are providing products and services that help reduce carbon emissions in the economy. We develop a methodology to identify those companies and create a sample of publicly listed climate solutions companies allowing us to study their...
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- 2023
- Working Paper
Won’t You Be My Neighbor? Events, Knowledge Spillovers, and Entrepreneur Performance in Togo
By: Stefan Dimitiadis and Rembrand Koning
Spatial proximity between firms plays a crucial role in entrepreneurship by creating knowledge spillovers, enabling resource sharing, and sparking productivity gains. Building on these insights, research has explored whether institutions and organizations can engineer...
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- January 2023
- Case
Cleave Therapeutics: Taking a Risk on Oncology Drug Discovery
By: Regina Herzlinger and Brian Walker
What should a successful executive (HBS Baker Scholar) assess as her next move as the CEO of a firm with a promising and yet uncertain new drug? Amy Burroughs’ mandate to successfully commercialize Cleave Therapeutics’ drug for a cancer with no current successful...
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