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  • 2023
  • Article

Association Between Regulatory Submission Characteristics and Recalls of Medical Devices Receiving 510(k) Clearance
By: Alexander O. Everhart, Soumya Sen, Ariel D. Stern, Yi Zhu and Pinar Karaca-Mandic
Importance: Most regulated medical devices enter the U.S. market via the 510(k) regulatory submission pathway, wherein manufacturers demonstrate that applicant devices are “substantially equivalent” to 1 or more “predicate” devices (legally marketed medical devices...  View Details
Keywords: Recalls; Governing Rules, Regulations, and Reforms; Medical Devices and Supplies Industry
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  • 2023
  • Article

The Power of Modularity Today: 20 years of 'Design Rules'
By: Stefano Brusoni, Joachim Henkel, Michael G Jacobides, Samina Karim, Alan MacCormack, Phanish Puranam and Melissa Schilling
In 2000, Carliss Baldwin and Kim Clark published “Design Rules: The Power of Modularity,” a book that introduced new ways of understanding and explaining the architecture of complex systems This Special Issue of Industrial and Corporate Change celebrates this seminal...  View Details
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  • January 2023
  • Case

Cleave Therapeutics: Taking a Risk on Oncology Drug Discovery
By: Regina Herzlinger and Brian Walker
How can a successful executive assess her next move as the CEO of a firm with a promising and yet uncertain new drug? Amy Burroughs’ mandate to find a therapeutic window for Cleave Therapeutics oncology drug was on track but faced an uncertain future. Overseeing the...  View Details
Keywords: Product Development; Leadership; Health Testing and Trials; Research and Development; Risk and Uncertainty; Financial Condition; Partners and Partnerships; Pharmaceutical Industry
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  • 2023
  • Working Paper

The Subjective Expected Utility Approach and a Framework for Defining Project Risk in Terms of Novelty and Feasibility—A Response to Franzoni and Stephan (2023), ‘Uncertainty and Risk-Taking in Science’
By: Jacqueline N. Lane
In their Discussion Paper, Franzoni and Stephan (F&S, 2023) discuss the shortcomings of existing peer review models in shaping the funding of risky science. Their discussion offers a conceptual framework for incorporating risk into peer review models of research...  View Details
Keywords: Risk and Uncertainty; Research; Resource Allocation; Perception
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  • 13 Dec 2022
  • Interview

Why Some Start-Ups Fail to Scale
By: Jeffrey Rayport and Curt Nickisch
Managing rapid growth is a huge challenge for young businesses. Even start-ups with glowing reviews and skyrocketing sales can fail. That’s because new ventures and corporate initiatives alike have to sustain profitability at scale, according to Harvard Business School...  View Details
Keywords: Business Startups; Growth Management; Outcome or Result; Transition
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  • December 8, 2022
  • Article

What Companies Still Get Wrong about Layoffs
By: Sandra J. Sucher and Marilyn Morgan Westner
Research has long shown that layoffs have a detrimental effect on individuals and on corporate performance. The short-term cost savings provided by a layoff are often overshadowed by bad publicity, loss of knowledge, weakened engagement, higher voluntary turnover, and...  View Details
Keywords: Resignation and Termination; Employment; Selection and Staffing; Performance
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  • December 2022
  • Background Note

Brief Note on Staggered Boards
By: Lynn S. Paine and Will Hurwitz
This background note discusses the evolution, use, and prevalence of staggered boards. By comparison with unitary boards whose members are all elected annually for one-year terms, staggered boards are divided into subsets of directors, with one subset up for election...  View Details
Keywords: Corporate Governance; Governing and Advisory Boards; Business History; Trends; Decision Choices and Conditions; United States
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  • 2022
  • Working Paper

Regulatory Incentives for Innovation: The FDA's Breakthrough Therapy Designation
By: Amitabh Chandra, Jennifer Kao, Kathleen Miller and Ariel D. Stern
Regulators of new products confront a tradeoff between speeding a new product to market and collecting additional product quality information. The FDA’s Breakthrough Therapy Designation (BTD) provides an opportunity to understand if a regulator can use new policy to...  View Details
Keywords: Research and Development; Governing Rules, Regulations, and Reforms; Product Development
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  • December 2022
  • Article

Shaping Nascent Industries: Innovation Strategy and Regulatory Uncertainty in Personal Genomics
By: Cheng Gao and Rory McDonald
In nascent industries—whose new technologies are often poorly understood by regulators—contending with regulatory uncertainty can be crucial to organizational survival and growth. Prior research on nonmarket strategy has largely focused on established firms in mature...  View Details
Keywords: Technological Change; Innovation; Qualitative Methods; New Categories; Entrepreneurship; Technological Innovation; Governing Rules, Regulations, and Reforms; Risk and Uncertainty; Strategy
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  • December 2022
  • Article

The Emotional Rewards of Prosocial Spending Are Robust and Replicable in Large Samples
By: Lara B. Aknin, Elizabeth W. Dunn and Ashley V. Whillans
Past studies show that spending money on other people—prosocial spending—increases a person’s happiness. However, foundational research on this topic was conducted prior to psychology’s credibility revolution (or “replication crisis”), so it is essential to ask...  View Details
Keywords: Happiness; Money
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  • December 2022
  • Article

When and How Should Firms Differentiate? Quality and Advertising Decisions in a Duopoly
By: Dominique Olié Lauga, Elie Ofek and Zsolt Katona
A prominent hallmark of competitive interaction is the desire to differentiate from rivals. In this article, the authors examine under what conditions firms will differentiate through product quality versus advertising intensity. Firms select quality in a first stage,...  View Details
Keywords: Competition; Advertising; Product Positioning
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  • 2022
  • Article

Which Explanation Should I Choose? A Function Approximation Perspective to Characterizing Post hoc Explanations
By: Tessa Han, Suraj Srinivas and Himabindu Lakkaraju
A critical problem in the field of post hoc explainability is the lack of a common foundational goal among methods. For example, some methods are motivated by function approximation, some by game theoretic notions, and some by obtaining clean visualizations. This...  View Details
Keywords: Mathematical Methods; Decision Choices and Conditions; Analytics and Data Science
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  • November 2022 (Revised December 2022)
  • Case

Replika AI: Monetizing a Chatbot
By: Julian De Freitas and Nicole Tempest Keller
In early 2018, Eugenia Kuyda, co-founder and CEO of San Francisco-based chatbot Replika AI, was deciding how to monetize the app she had built. Launched in 2017, Replika was a consumer AI “companion app” developed by a team of AI software engineers originally based in...  View Details
Keywords: Mental Health; Subscriber Models; TAM; Monetization Strategy; Marketing Strategy; Product Marketing; AI and Machine Learning; Applications and Software; Product Positioning; Health Disorders; Technology Industry
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  • November 22, 2022
  • Article

Is Novel Research Worth Doing? Evidence from Peer Review at 49 Journals
By: Misha Teplitskiy, Hao Peng, Andrea Blasco and Karim R. Lakhani
There are long-standing concerns that peer review, which is foundational to scientific institutions like journals and funding agencies, favors conservative ideas over novel ones. We investigate the association between novelty and the acceptance of manuscripts submitted...  View Details
Keywords: Research; Journals and Magazines
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  • November 2022 (Revised January 2023)
  • Case

Hugging Face: Serving AI on a Platform
By: Shane Greenstein, Daniel Yue, Kerry Herman and Sarah Gulick
It is fall 2022, and open-source AI model company Hugging Face is considering its three areas of priorities: platform development, supporting the open-source community, and pursuing cutting-edge scientific research. As it expands services for enterprise clients, which...  View Details
Keywords: Community; Open-source; AI and Machine Learning; Product Development; Networks; Service Delivery; Research; Governance; Business and Stakeholder Relations; Information Industry; Technology Industry; United States
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  • 2022
  • Article

A Human-Centric Take on Model Monitoring
By: Murtuza Shergadwala, Himabindu Lakkaraju and Krishnaram Kenthapadi
Predictive models are increasingly used to make various consequential decisions in high-stakes domains such as healthcare, finance, and policy. It becomes critical to ensure that these models make accurate predictions, are robust to shifts in the data, do not rely on...  View Details
Keywords: AI and Machine Learning; Research and Development; Demand and Consumers
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  • November 2022
  • Article

Measuring Inequality beyond the Gini Coefficient May Clarify Conflicting Findings
By: Kristin Blesch, Oliver P. Hauser and Jon M. Jachimowicz
Prior research has found mixed results on how economic inequality is related to various outcomes. These contradicting findings may in part stem from a predominant focus on the Gini coefficient, which only narrowly captures inequality. Here, we conceptualize the...  View Details
Keywords: Economic Inequalty; Gini Coefficient; Income Inequality; Equality and Inequality; Social Issues; Health; Status and Position
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  • November 2022
  • Article

My Boss' Passion Matters as Much as My Own: The Interpersonal Dynamics of Passion Are a Critical Driver of Performance Evaluations
By: Jon M. Jachimowicz, Andreas Wihler and Adam D. Galinsky
Companies often celebrate employees who successfully pursue their passion. Academic research suggests that these positive evaluations occur because of the passion percolating inside the employee. We propose that supervisors are also a key piece of this puzzle:...  View Details
Keywords: Passion; Job Performance; Motivation; Emotions; Performance Evaluation; Interpersonal Communication
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  • November–December 2022
  • Article

To See the Way Forward, Look Back
By: Ranjay Gulati
Most business leaders focus on the future much more than on the past, believing that their job is to embrace disruption and innovation, transform their organizations, and explore new frontiers. But decades of research on companies worldwide shows that most successful...  View Details
Keywords: Values and Beliefs; Transformation; Mission and Purpose; Leadership
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  • 13 Oct 2022
  • Other Presentation

4 Business Ideas That Changed the World: Disruptive Innovation
By: Amy Bernstein, Rita McGrath, Felix Oberholzer-Gee and Derek van Bever
A roundtable conversation takes stock of Clayton Christensen’s influential theory. This first in a series of roundtable conversations assessing the origins and impact of four breakthrough ideas.

In the 1980s, Clayton Christensen cofounded a startup that...  View Details
Keywords: Disruptive Innovation
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