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All HBS Web
(1,212)
- Faculty Publications (97)
- 2021
- Working Paper
Development of CAR-T Therapies: Case Histories of Significant Medical Advances
By: Amar Bhidé and Srikant M. Datar
In 2017, the US Food and Drug Administration (FDA) approved an immunotherapeutic treatment, called CAR-T therapy, for two kinds of blood cancers—acute leukemia (ALL) and a lymphoma. We describe 1) how CAR-T works; 2) the foundational advances and discoveries; 3)...
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Keywords:
Immunotherapy;
Health Care and Treatment;
Innovation and Invention;
Research and Development;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, and Srikant M. Datar. "Development of CAR-T Therapies: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 21-035, August 2020. (Revised May 2021.)
- August 18, 2020
- Article
What It Takes to Lead a Disease Research Foundation
By: Richard G. Hamermesh and Kathy Giusti
Hamermesh, Richard G., and Kathy Giusti. "What It Takes to Lead a Disease Research Foundation." Harvard Business Review Digital Articles (August 18, 2020).
- 2021
- Working Paper
Cephalosporins: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant Datar and Katherine Stebbins
Our case history describes the development of three generations of cephalosporins—antibiotics that have significantly reduced hospital infections. After providing an overview of antibiotic development and its challenges we describe how: 1) Early (pre-cephalosporin)...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant Datar, and Katherine Stebbins. "Cephalosporins: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-133, July 2020. (Revised May 2021.)
- 2021
- Working Paper
SSRIs and Non-SSRIs (through 1999): Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Our case history describes the development of Prozac, a blockbuster drug that transformed the treatment of depression – and became a cultural phenomenon in the United States. Specifically, we chronicle the: 1) prior treatments for depression and the research that...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "SSRIs and Non-SSRIs (through 1999): Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-135, July 2020. (Revised June 2021.)
- March 2020
- Case
A Tower for the People: 425 Park Avenue
By: John Macomber, Joseph G. Allen and Emily Jones
Healthy buildings and superior air quality are increasingly important since people now spend so much time indoors. Indoor spaces drive performance and productivity. Commercial real estate landlords and investors are responding to the demands of sophisticated tenants...
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Keywords:
Health And Wellness;
Real Estate;
Sustainability;
Health;
Pollution;
Buildings and Facilities;
Performance Productivity;
Finance;
Real Estate Industry;
New York (city, NY)
Macomber, John, Joseph G. Allen, and Emily Jones. "A Tower for the People: 425 Park Avenue." Harvard Business School Case 220-065, March 2020.
- November 2018
- Article
Disruptive Innovation: An Intellectual History and Directions for Future Research
The concept of disruptive innovation has gained considerable currency among practitioners despite widespread misunderstanding of its core principles. Similarly, foundational research on disruption has elicited frequent citation and vibrant debate in academic circles,...
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Keywords:
Innovation Metrics;
Systemic Industries;
Technology Trajectories;
Disruptive Innovation;
Theory;
History;
Competitive Strategy;
Research
Christensen, Clayton M., Rory McDonald, Elizabeth J. Altman, and Jonathan E. Palmer. "Disruptive Innovation: An Intellectual History and Directions for Future Research." Special Issue on Managing in the Age of Disruptions. Journal of Management Studies 55, no. 7 (November 2018): 1043–1078.
- March–April 2017
- Article
Advancing Conservation by Understanding and Influencing Human Behavior
By: Sheila M. Reddy, Jensen Montambault, Yuta J. Masuda, Ayelet Gneezy, Elizabeth Keenan, William Butler, Jonathan R. Fisher and Stanley T. Asah
Behavioral sciences can advance conservation by systematically identifying behavioral barriers to conservation and how to best overcome them. Behavioral sciences have informed policy in many other realms (e.g., health, savings), but they are a largely untapped resource...
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Keywords:
Adaptive Management;
Awareness;
Behavioral Economics;
Behavioral Science;
Conservation Intervention;
Conservation Planning;
Decision-making;
Incentives;
Nudge;
Management;
Motivation and Incentives;
Behavior;
Marketing;
Decision Making;
Environmental Sustainability;
Economics
Reddy, Sheila M., Jensen Montambault, Yuta J. Masuda, Ayelet Gneezy, Elizabeth Keenan, William Butler, Jonathan R. Fisher, and Stanley T. Asah. "Advancing Conservation by Understanding and Influencing Human Behavior." Conservation Letters 10, no. 2 (March–April 2017): 248–256. (doi:10.1111/conl.12252.)
- June 2016 (Revised August 2019)
- Case
Numenta: Inventing and (or) Commercializing AI
By: David B. Yoffie, Liz Kind and David Ben Shimol
In March 2016, Donna Dubinsky (co-founder and CEO) and Jeff Hawkins (co-founder) were struggling with a key question: Could Numenta be successful in both creating fundamental technology and building a commercial business? Located in Redwood City, CA, Numenta was...
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Keywords:
Artificial Intelligence;
Machine Intelligence;
Machine Learning;
Strategy;
Business Model;
Entrepreneurship;
Information;
Technological Innovation;
Research;
Research and Development;
Information Technology;
Applications and Software;
Technology Adoption;
Digital Platforms;
Commercialization;
AI and Machine Learning
Yoffie, David B., Liz Kind, and David Ben Shimol. "Numenta: Inventing and (or) Commercializing AI." Harvard Business School Case 716-469, June 2016. (Revised August 2019.)
- October 2015
- Case
The Maine Food Cluster Project
By: Karen Mills and Aldo Sesia
The Libra Foundation is exploring how to grow the food sector in Maine using the strategy of creating a food cluster initiative. Maine is one of the poorest states in the United States and the food sector is one of the largest employers. Multiple efforts in...
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Keywords:
Development Economics;
Food and Beverage Industry;
Agriculture and Agribusiness Industry;
Maine;
Vermont;
Oregon;
Denmark
Mills, Karen, and Aldo Sesia. "The Maine Food Cluster Project." Harvard Business School Case 316-008, October 2015.
- 2015
- Book
Strong Brands, Strong Relationships
By: Susan Fournier, Michael Breazeale and Jill Avery
From the editorial team of the ground-breaking Consumer-Brand Relationships: Theory and Practice comes this new volume. Strong Brands, Strong Relationships is a collection of innovative research and management insights that build upon the foundations of...
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Keywords:
Brand Building;
Brand Management;
CRM;
Marketing;
Brands and Branding;
Marketing Communications;
Advertising;
Customer Relationship Management;
Customer Focus and Relationships;
Advertising Industry;
Apparel and Accessories Industry;
Consumer Products Industry
Fournier, Susan, Michael Breazeale and Jill Avery, eds. Strong Brands, Strong Relationships. Abingdon, UK: Routledge, 2015.
- 2015
- Chapter
Diversity in Groups
By: Catarina Fernandes and Jeff Polzer
Diversity has the potential to either disrupt group functioning or, conversely, be the source of collective creativity and insight. These two divergent perspectives pose a paradox that has held the attention of scholars for many years. In response, researchers have...
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Fernandes, Catarina, and Jeff Polzer. "Diversity in Groups." In Emerging Trends in the Social and Behavioral Sciences: An Interdisciplinary, Searchable, and Linkable Resource, edited by Robert A. Scott and Stephen M. Kosslyn. Hoboken, NJ: John Wiley & Sons, 2015. Electronic.
- 2014
- Working Paper
The Nobel Prize: A 'Heritage-based' Brand-oriented Network
By: Mats Urde and Stephen A. Greyser
Purpose — Understanding the Nobel Prize as a 'true' heritage brand in a networked situation and its management challenges, especially regarding identity and reputation.
Methodology — The Nobel Prize serves as an in-depth case study and is analysed within... View Details
Methodology — The Nobel Prize serves as an in-depth case study and is analysed within... View Details
Keywords:
Nobel Prize;
Heritage Brand;
Brand Network;
Networked Brand;
Brand Within A Network;
Brand Orientation;
Brand Stewardship;
Corporate Brand Identity;
Reputation;
Networks;
Organizations;
Philanthropy and Charitable Giving;
Brands and Branding
Urde, Mats, and Stephen A. Greyser. "The Nobel Prize: A 'Heritage-based' Brand-oriented Network." Harvard Business School Working Paper, No. 15-010, August 2014.
- Article
Past, Present and Future Research on Multiple Identities: Toward an Intrapersonal Network Approach
Psychologists, sociologists, and philosophers have long recognized that people have multiple identities—based on attributes such as organizational membership, profession, gender, ethnicity, religion, nationality, and family role(s) and that these multiple identities...
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Ramarajan, Lakshmi. "Past, Present and Future Research on Multiple Identities: Toward an Intrapersonal Network Approach." Academy of Management Annals 8 (2014): 589–659.
- June 2014 (Revised February 2017)
- Case
Kathy Giusti and the Multiple Myeloma Research Foundation
By: Richard G. Hamermesh, Joshua D. Margolis and Matthew G. Preble
What do you do when your rising professional career is cut short by an unexpected cancer diagnosis? Kathy Giusti shifted careers, built a new organization that transformed how cancer research is done, and now faces the challenge of sustaining the organization and its...
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Keywords:
Philanthropy;
Philanthropy Funding;
Entrepreneurship;
Health Care;
Management Styles;
Personalized Medicine;
Health Care Outcomes;
Cancer;
Cancer Care In The U.S.;
Personal Care;
Leadership;
Leading Change;
Social Entrepreneurship;
Philanthropy and Charitable Giving;
Health Care and Treatment;
Leadership Style;
Management Style;
Management Skills;
Growth and Development Strategy;
Business Strategy;
Health;
Health Industry;
United States;
Canada;
Spain
Hamermesh, Richard G., Joshua D. Margolis, and Matthew G. Preble. "Kathy Giusti and the Multiple Myeloma Research Foundation." Harvard Business School Case 814-026, June 2014. (Revised February 2017.)
- 2014
- Chapter
Schumpeter's Plea: Historical Reasoning in Entrepreneurial Theory and Research
By: G. Jones and R. Daniel Wadhwani
This chapter draws on theories of entrepreneurship and history to explore the ways in which historical processes play an integral role in entrepreneurship. It builds off the plea by Joseph Schumpeter for an active exchange between historical approaches and theories of...
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Jones, G., and R. Daniel Wadhwani. "Schumpeter's Plea: Historical Reasoning in Entrepreneurial Theory and Research." Chap. 8 in Organizations in Time: History, Theory, Methods, edited by Marcelo Bucheli and R. Daniel Wadhwani, 192–216. New York: Oxford University Press, 2014.
- 2014
- Book
Business History
By: Walter A. Friedman and Geoffrey Jones
This volume contains a selection of 42 foundational articles on the discipline of business history written between 1934 and the present day by scholars based in the United States, Europe, Asia, and Latin America. A wide-ranging editorial introduction describes the...
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Friedman, Walter A. and Geoffrey Jones, eds. Business History. Northampton, MA: Edward Elgar Publishing, 2014.
- October 2013
- Article
How Much to Make and How Much to Buy? An Analysis of Optimal Plural Sourcing Strategies
By: Phanish Puranam, Ranjay Gulati and Sourav Bhattacharya
While many theories of the firm seek to explain when firms make rather than buy, in practice, firms often make and buy the same input—they engage in plural sourcing. We argue that explaining the mix of external procurement and internal sourcing for the same input...
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Keywords:
Supply Chain;
Forecasting and Prediction;
Framework;
Prejudice and Bias;
Mathematical Methods
Puranam, Phanish, Ranjay Gulati, and Sourav Bhattacharya. "How Much to Make and How Much to Buy? An Analysis of Optimal Plural Sourcing Strategies." Strategic Management Journal 34, no. 10 (October 2013): 1145–1161.
- 2013
- Working Paper
Management: Theory and Practice, and Cases
By: Richard L. Nolan
This working paper reports on a major Harvard Business School project designed to enhance MBA and practicing executives in case learning. The work is built on the foundation of HBS field cases employing the monomyth "hero's journey" classic story structure along... View Details
Keywords:
Innovation;
CIO;
CEO;
Hero's Journey;
Monomyth;
Management;
Practice;
Cases;
Theory;
Innovation and Invention
Nolan, Richard L. "Management: Theory and Practice, and Cases." Harvard Business School Working Paper, No. 14-026, September 2013.
- July 2013
- Technical Note
Competition Simulator Exercise: Questions
In the Competition Simulator Exercise, students explore through trial and error some important economic foundations of competitive strategy and managerial economics. In particular, the simulator lets students explore horizontal differentiation with and without price...
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Keywords:
Economics Of Strategy;
Economics Of Competition;
Competition;
Economics;
Game Theory;
Competitive Strategy;
Marketing Strategy
Van den Steen, Eric. "Competition Simulator Exercise: Questions." Harvard Business School Technical Note 714-406, July 2013.
- June 2013 (Revised November 2022)
- Exercise
Competition Simulator Exercise
In the Competition Simulator Exercise, students explore through trial and error some important economic foundations of competitive strategy and managerial economics. In particular, the nine simulator exercises let students explore horizontal differentiation with and...
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Keywords:
Competition;
Economics;
Game Theory;
Competitive Strategy;
Learning;
Mathematical Methods;
Analysis
Van den Steen, Eric J. "Competition Simulator Exercise." Harvard Business School Exercise 713-804, June 2013. (Revised November 2022.)