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      • January 2023
      • Case

      Cleave Therapeutics: Taking a Risk on Oncology Drug Discovery

      By: Regina Herzlinger and Brian Walker
      How can a successful executive assess her next move as the CEO of a firm with a promising and yet uncertain new drug? Amy Burroughs’ mandate to find a therapeutic window for Cleave Therapeutics oncology drug was on track but faced an uncertain future. Overseeing the...  View Details
      Keywords: Product Development; Leadership; Health Testing and Trials; Research and Development; Risk and Uncertainty; Financial Condition; Partners and Partnerships; Pharmaceutical Industry
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      Herzlinger, Regina, and Brian Walker. "Cleave Therapeutics: Taking a Risk on Oncology Drug Discovery." Harvard Business School Case 323-045, January 2023.
      • Working Paper

      Diversification as an Adaptive Learning Process: An Empirical Study of General-Purpose and Market-Specific Technological Know-How in New Market Entry

      By: Dominika Kinga Randle and Gary P. Pisano
      An enduring trait of modern corporations is their propensity to diversify into multiple lines of business. Penrosian theories conceptualize diversification as a strategy to exploit a firm’s fungible, yet “untradeable,” resources and point to redeployment of...  View Details
      Keywords: Growth and Development Strategy; Technology Adoption; Diversification; Market Entry and Exit; Transformation
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      Randle, Dominika Kinga, and Gary P. Pisano. "Diversification as an Adaptive Learning Process: An Empirical Study of General-Purpose and Market-Specific Technological Know-How in New Market Entry." Harvard Business School Working Paper, No. 23-032, December 2022.
      • 2022
      • Working Paper

      Regulatory Incentives for Innovation: The FDA's Breakthrough Therapy Designation

      By: Amitabh Chandra, Jennifer Kao, Kathleen Miller and Ariel D. Stern
      Regulators of new products confront a tradeoff between speeding a new product to market and collecting additional product quality information. The FDA’s Breakthrough Therapy Designation (BTD) provides an opportunity to understand if a regulator can use new policy to...  View Details
      Keywords: Research and Development; Governing Rules, Regulations, and Reforms; Product Development
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      Chandra, Amitabh, Jennifer Kao, Kathleen Miller, and Ariel D. Stern. "Regulatory Incentives for Innovation: The FDA's Breakthrough Therapy Designation." NBER Working Paper Series, No. 30712, December 2022.
      • December 2022 (Revised December 2022)
      • Case

      Ribbit Capital and the Gauntlet Investment Opportunity

      By: Shai Bernstein and Allison M. Ciechanover
      Ten-year-old, Palo Alto-based Ribbit Capital is best-known for its global investments in fintech. The firm was also an early advocate of crypto and blockchain, having invested in more than two dozen startups in the space in the past decade. In the Spring of 2022,...  View Details
      Keywords: Alternative Assets; Cryptocurrency; Business Startups; Investment Portfolio; Decision Choices and Conditions; Negotiation Deal; Governing Rules, Regulations, and Reforms; Financial Services Industry; California
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      Bernstein, Shai, and Allison M. Ciechanover. "Ribbit Capital and the Gauntlet Investment Opportunity." Harvard Business School Case 823-038, December 2022. (Revised December 2022.)
      • December 2022
      • Article

      Shaping Nascent Industries: Innovation Strategy and Regulatory Uncertainty in Personal Genomics

      By: Cheng Gao and Rory McDonald
      In nascent industries—whose new technologies are often poorly understood by regulators—contending with regulatory uncertainty can be crucial to organizational survival and growth. Prior research on nonmarket strategy has largely focused on established firms in mature...  View Details
      Keywords: Technological Change; Innovation; Qualitative Methods; New Categories; Entrepreneurship; Technological Innovation; Governing Rules, Regulations, and Reforms; Risk and Uncertainty; Strategy
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      Gao, Cheng, and Rory McDonald. "Shaping Nascent Industries: Innovation Strategy and Regulatory Uncertainty in Personal Genomics." Administrative Science Quarterly 67, no. 4 (December 2022): 915–967.
      • 2022
      • Working Paper

      The Regulation of Medical AI: Policy Approaches, Data, and Innovation Incentives

      By: Ariel Dora Stern
      For those who follow health and technology news, it is difficult to go more than a few days without reading about a compelling new application of Artificial Intelligence (AI) to health care. AI has myriad applications in medicine and its adjacent industries, with...  View Details
      Keywords: AI and Machine Learning; Health Care and Treatment; Governing Rules, Regulations, and Reforms; Technological Innovation; Medical Devices and Supplies Industry
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      Stern, Ariel Dora. "The Regulation of Medical AI: Policy Approaches, Data, and Innovation Incentives." NBER Working Paper Series, No. 30639, December 2022.
      • November 2022
      • Case

      Ajax Health: A New Model for Medical Technology Innovation

      By: Regina E. Herzlinger and Ben Creo
      This case teaches key success factors for both startups and established medtech firms. It examines how to structure a firm to maximize financial returns. Medtech entrepreneur Duke Rohlen is proposing a new model for innovation and business growth. From 2007 to 2019,...  View Details
      Keywords: Business Startups; Success; Innovation Strategy; Mergers and Acquisitions; Market Entry and Exit; Financial Strategy; Business Model; Partners and Partnerships; Entrepreneurship; Private Equity; Technology Industry; Medical Devices and Supplies Industry
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      Herzlinger, Regina E., and Ben Creo. "Ajax Health: A New Model for Medical Technology Innovation." Harvard Business School Case 323-043, November 2022.
      • November 2022
      • Article

      A Language-Based Method for Assessing Symbolic Boundary Maintenance between Social Groups

      By: Anjali M. Bhatt, Amir Goldberg and Sameer B. Srivastava
      When the social boundaries between groups are breached, the tendency for people to erect and maintain symbolic boundaries intensifies. Drawing on extant perspectives on boundary maintenance, we distinguish between two strategies that people pursue in maintaining...  View Details
      Keywords: Culture; Machine Learning; Natural Language Processing; Symbolic Boundaries; Organizations; Boundaries; Social Psychology; Interpersonal Communication; Organizational Culture
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      Bhatt, Anjali M., Amir Goldberg, and Sameer B. Srivastava. "A Language-Based Method for Assessing Symbolic Boundary Maintenance between Social Groups." Sociological Methods & Research 51, no. 4 (November 2022): 1681–1720.
      • 2022
      • Working Paper

      The Evolution of ESG Reports and the Role of Voluntary Standards

      By: Ethan Rouen, Kunal Sachdeva and Aaron Yoon
      We examine the evolution of ESG reports of S&P 500 firms from 2010 to 2021. The percentage of firms releasing these voluntary disclosures increased from 35% to 86% during this period, although the length of these documents experienced more modest growth. Using a...  View Details
      Keywords: Voluntary Disclosure; Textual Analysis; Modeling And Analysis; Corporate Social Responsibility and Impact; AI and Machine Learning; Accounting
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      Rouen, Ethan, Kunal Sachdeva, and Aaron Yoon. "The Evolution of ESG Reports and the Role of Voluntary Standards." Harvard Business School Working Paper, No. 23-024, October 2022.
      • 2022
      • Working Paper

      You've Got Mail! The Late 19th Century U.S. Postal Service Expansion, Entrepreneurship, and Firm Performance

      By: Astrid Marinoni and Maria P. Roche
      We analyze the impact of the US Postal Service's western expansion in the late 19th century, a major institutional innovation, on entrepreneurship and its heterogeneous influence on firm performance. Exploiting a novel dataset constructed from digitized archival...  View Details
      Keywords: Entrepreneurship; Institutional Innovation; Knowledge Exchange; US Postal Service; Firm Performance; Infrastructure; Expansion; Government Administration; Communication; Business History; Public Administration Industry; California
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      Marinoni, Astrid, and Maria P. Roche. "You've Got Mail! The Late 19th Century U.S. Postal Service Expansion, Entrepreneurship, and Firm Performance." Harvard Business School Working Paper, No. 23-022, October 2022.
      • October 2022
      • Case

      mPharma: Scaling Access to Affordable Primary Care in Africa

      By: Regina E. Herzlinger and Ben Creo
      mPharma CEO Greg Rockson is attempting to create the largest pan-African primary healthcare company. He must evaluate a three-year strategy potentially involving three key components: a rapid and extensive expansion of the company's network of 600 retail pharmacies in...  View Details
      Keywords: Africa; Pharmaceutical Companies; Pharmacy Benefit Manager; Health Care; Health Care And Treatment; Health Care Costs; Health Care Delivery; Health Care Entrepreneurship; Telehealth; Health Equity; Corporate Strategy; Social Entrepreneurship; Equity; Growth and Development Strategy; Expansion; Product Launch; Customer Value and Value Chain; Social Enterprise; Multinational Firms and Management; Pharmaceutical Industry; Health Industry; Africa
      Citation
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      Herzlinger, Regina E., and Ben Creo. "mPharma: Scaling Access to Affordable Primary Care in Africa." Harvard Business School Case 323-033, October 2022.
      • 2022
      • Working Paper

      Buy Now, Pay Later Credit: User Characteristics and Effects on Spending Patterns

      By: Marco Di Maggio, Emily Williams and Justin Katz
      Firms offering "buy now, pay later" (BNPL) point-of-sale installment loans with minimal underwriting and low interest have captured a growing fraction of the market for short-term unsecured consumer credit. We provide a detailed look into the US BNPL market by...  View Details
      Keywords: Household Finance; Fintech; Consumer Credit; Credit; Consumer Behavior
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      Di Maggio, Marco, Emily Williams, and Justin Katz. "Buy Now, Pay Later Credit: User Characteristics and Effects on Spending Patterns." NBER Working Paper Series, No. 30508, September 2022.
      • 2022
      • White Paper

      The American Opportunity Index: A Corporate Scorecard of Worker Advancement

      By: Matt Sigelman, Joseph Fuller, Nik Dawson and Gad Levanon
      The American Opportunity Index: A Corporate Scorecard of Worker Advancement is a new effort to give companies and other stakeholders a set of robust tools that measure how well major employers are doing in fostering economic mobility for workers and how they could do...  View Details
      Keywords: Upward Mobility; Career Advancement; Personal Development and Career; Compensation and Benefits; Employees; Wages; Human Capital; Recruitment
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      Sigelman, Matt, Joseph Fuller, Nik Dawson, and Gad Levanon. "The American Opportunity Index: A Corporate Scorecard of Worker Advancement." White Paper, Burning Glass Institute, October 2022 (A joint project with Harvard Business School Project on Managing the Future of Work and Schultz Family Foundation.)
      • 2022
      • Article

      Dynamic Pricing Algorithms, Consumer Harm, and Regulatory Response

      By: Alexander MacKay and Samuel N. Weinstein
      Pricing algorithms are rapidly transforming markets, from ride-sharing apps, to air travel, to online retail. Regulators and scholars have watched this development with a wary eye. Their focus so far has been on the potential for pricing algorithms to facilitate...  View Details
      Keywords: Competition Policy; Regulation; Algorithmic Pricing; Dynamic Pricing; Economics; Law And Economics; Law And Regulation; Consumer Protection; Antitrust Law; Industrial Organization; Antitrust Issues And Policies; Technological Change: Choices And Consequences; Competition; Policy; Price; Governing Rules, Regulations, and Reforms; Microeconomics; Duopoly and Oligopoly; Law
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      MacKay, Alexander, and Samuel N. Weinstein. "Dynamic Pricing Algorithms, Consumer Harm, and Regulatory Response." Washington University Law Review 100, no. 1 (2022): 111–174. (Direct download.)
      • September 2022
      • Article

      Experimentation and Startup Performance: Evidence from A/B Testing

      By: Rembrand Koning, Sharique Hasan and Aaron Chatterji
      Recent scholarship has argued that experimentation should be the organizing principle for entrepreneurial strategy. Experimentation leads to organizational learning, which drives improvements in firm performance. We investigate this proposition by exploiting the...  View Details
      Keywords: Experimentation; A/B Testing; Data-driven Decision-making; Organizational Learning; Entrepreneurship; Strategy; Business Startups; Learning; Performance; Decision Making
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      Koning, Rembrand, Sharique Hasan, and Aaron Chatterji. "Experimentation and Startup Performance: Evidence from A/B Testing." Management Science 68, no. 9 (September 2022): 6434–6453.
      • August 2022
      • Case

      Bajaj Finance: Building an Omnipresent Financial Services Firm

      By: Das Narayandas and Rachna Tahilyani
      Bajaj Finance, India’s largest consumer finance firm with $20.9 billion of assets across 50.5 million customers, is on a journey to transform itself from a traditional firm that sells loans and other financial products through brick-and-mortar outlets to an omnipresent...  View Details
      Keywords: Financial Institutions; Transformation; Financial Instruments; Customer Satisfaction; Internet and the Web; Customer Focus and Relationships; India
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      Narayandas, Das, and Rachna Tahilyani. "Bajaj Finance: Building an Omnipresent Financial Services Firm." Harvard Business School Case 523-040, August 2022.
      • 2022
      • Working Paper

      Do Job Seekers Value Diversity Information? Evidence from a Field Experiment and Human Capital Disclosures

      By: Jung Ho Choi, Joseph Pacelli, Kristina M. Rennekamp and Sorabh Tomar
      We examine how information about the diversity of a potential employer’s workforce affects individuals’ job-seeking behavior. We embed a field experiment in job recommendation emails sent from a leading career advice agency in the U.S. The experimental treatment...  View Details
      Keywords: Diversity; Job Search; Human Capital Disclosure; Field Experiment; Recruitment
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      Choi, Jung Ho, Joseph Pacelli, Kristina M. Rennekamp, and Sorabh Tomar. "Do Job Seekers Value Diversity Information? Evidence from a Field Experiment and Human Capital Disclosures." Harvard Business School Working Paper, No. 23-019, August 2022.
      • August 2022
      • Article

      When the Local Newspaper Leaves Town: The Effects of Local Newspaper Closures on Corporate Misconduct

      By: Jonas Heese, Gerardo Pérez Cavazos and Caspar David Peter
      We examine whether the local press is an effective monitor of corporate misconduct. Specifically, we study the effects of local newspaper closures on violations by local facilities of publicly listed firms. After a local newspaper closure, local facilities increase...  View Details
      Keywords: Corporate Misconduct; Local Newspapers; Media Coverage; Firm Monitoring; Newspapers
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      Heese, Jonas, Gerardo Pérez Cavazos, and Caspar David Peter. "When the Local Newspaper Leaves Town: The Effects of Local Newspaper Closures on Corporate Misconduct." Journal of Financial Economics 145, nos. 2, Part B (August 2022).
      • June 29, 2022
      • Other Article

      Strategic Complexity? Using Experiments to Understand and Overcome Obfuscation

      By: Michael Luca, Ginger Zhe Jin and Daniel Martin
      Credit card companies must decide what product features to disclose to consumers, such as payment schedules, penalties, and fees--and also whether to present them clearly or bury them in the fine print. Firms face similar choices in settings ranging from privacy...  View Details
      Keywords: Obfuscation; Credit Cards; Strategic Incentives; Complexity; Agreements and Arrangements; Customers; Consumer Behavior; Financial Services Industry
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      Luca, Michael, Ginger Zhe Jin, and Daniel Martin. "Strategic Complexity? Using Experiments to Understand and Overcome Obfuscation." Management Science Review (June 29, 2022). (Summary of "Complex Disclosure," Management Science, May 2022.)
      • July 2022
      • Supplement

      Solution for E-Commerce Analytics for CPG Firms (B): Optimizing Assortment for a New Retailer

      By: Ayelet Israeli
      Keywords: Data; Data Analysis; Data Analytics; Data Sharing; CPG; Consumer Packaged Goods (CPG); Delivery Planning; Customer Lifetime Value; Online Channel; Retail; Retail Analytics; Retailing Industry; Ecommerce; Grocery; Optimization; Analytics and Data Science; Analysis; Customer Value and Value Chain; Marketing Channels; E-commerce; Retail Industry; Consumer Products Industry; United States
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      Israeli, Ayelet. "Solution for E-Commerce Analytics for CPG Firms (B): Optimizing Assortment for a New Retailer." Harvard Business School Spreadsheet Supplement 523-705, July 2022.
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