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- 2021
- Working Paper
The Anatomy of a Hospital System Merger: The Patient Did Not Respond Well to Treatment
By: Martin Gaynor, Adam Sacarny, Raffaella Sadun, Chad Syverson and Shruthi Venkatesh
There is an ongoing merger wave in the U.S. hospital industry, but it remains an open question how hospital mergers change, or fail to change, hospital behavior, performance, and outcomes. In this research, we open the “black box” of practices within hospitals in the...
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- July 2021
- Article
Making Medications Stick: Improving Medication Adherence by Highlighting the Personal Health Costs of Non-compliance
By: Jon M. Jachimowicz, Joe J. Gladstone, Dan Berry, Charlotte L. Kirkdale, Tracey Thornley and Adam D. Galinsky
Poor compliance of prescription medication is an ongoing public health crisis. Nearly half of patients do not take their medication as prescribed, harming their own health while also increasing public health care costs. Despite these detrimental consequences, prior...
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- June 2021
- Article
Engineering Serendipity: When Does Knowledge Sharing Lead to Knowledge Production?
By: Jacqueline N. Lane, Ina Ganguli, Patrick Gaule, Eva C. Guinan and Karim R. Lakhani
We investigate how knowledge similarity between two individuals is systematically related to the likelihood that a serendipitous encounter results in knowledge production. We conduct a natural field experiment at a medical research symposium, where we exogenously...
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- Article
Use of Connected Digital Products in Clinical Research Following the COVID-19 Pandemic: A Comprehensive Analysis of Clinical Trials
By: Caroline Marra, William J. Gordon and Ariel Dora Stern
Objectives: In an effort to mitigate COVID-19 related challenges for clinical research, the U.S. Food and Drug Administration (FDA) issued new guidance for the conduct of ‘virtual’ clinical trials in late March 2020. This study documents trends in the use of...
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- May 2021
- Case
Inclusive Innovation at Mass General Brigham
By: Katherine Baldiga Coffman and Olivia Hull
Massachusetts General Brigham (MGB) Chief Innovation Officer Christopher Coburn had overseen a period of exciting transformation and growth in healthcare innovation at MGB. In November 2019, the health system was the largest recipient of National Institutes of Health...
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Keywords:
Inclusion;
Innovation;
Invention;
Gender;
Business Startups;
Investment Funds;
Private Equity;
Health Care and Treatment;
Innovation Strategy;
Technological Innovation;
Intellectual Property;
Copyright;
Patents;
Research;
Research and Development;
Diversification;
Technology;
Health Industry;
Massachusetts;
Boston
- May 2021
- Case
The SMA Foundation: Steering Therapeutic Research and Development in a Rare Disease
By: Amitabh Chandra, Spencer Lee-Rey and Caroline Marra
This case explores incentives for rare disease drug development by chronicling the role of the Spinal Muscular Atrophy (SMA) Foundation in forming strategic partnerships with the scientific research community and pharmaceutical developers to transform the trajectory...
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- May 2021
- Article
Value-Based Healthcare in Urology: A Collaborative Review
By: Chanan Reitblat, Paul A. Bain, Michael E. Porter, David N. Bernstein, Thomas W. Feeley, Markus Graefen, Santosh Iyer, Matthew J. Resnick, C.J. Stimson, Quoc-Dien Trinh and Boris Gershman
Context:
In response to growing concerns over rising costs and major variation in quality, improving value for patients has been proposed as a fundamentally new strategy for how healthcare should be delivered, measured, and... View Details
In response to growing concerns over rising costs and major variation in quality, improving value for patients has been proposed as a fundamentally new strategy for how healthcare should be delivered, measured, and... View Details
- January 28, 2021
- Other Article
Lessons from the U.S.'s Rocky Vaccine Rollout
By: Robert S. Huckman and Bradley R. Staats
The rocky rollout of the COVID-19 vaccines is emblematic of many of the problems with the U.S. health care system. The United States is blessed with highly trained, excellent, and compassionate care providers and terrific research and development that has led to novel...
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- 2020
- Working Paper
The Market for Healthcare in Low Income Countries
By: Reshmaan Hussam, Abhijit Banerjee, Jishnu Das, Jeffrey Hammer and Aakash Mohpal
New research clearly identifies trust as an important driver of the demand for healthcare. However, doctors who realize that patients may not trust them may also alter their behavior in response. We assemble a large dataset that assesses clinical performance using...
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- 2021
- Working Paper
Development of CAR-T Therapies: Case Histories of Significant Medical Advances
By: Amar Bhidé and Srikant M. Datar
In 2017, the US Food and Drug Administration (FDA) approved an immunotherapeutic treatment, called CAR-T therapy, for two kinds of blood cancers—acute leukemia (ALL) and a lymphoma. We describe 1) how CAR-T works; 2) the foundational advances and discoveries; 3)...
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- August 2020 (Revised October 2020)
- Case
1928 Diagnostics: Fighting Antibiotics Resistance
By: Ariel D. Stern and Daniela Beyersdorfer
In 2019, the co-founders of the Swedish medical start-up 1928 Diagnostics, CEO Dr. Kristina Lagerstedt and COO Dr. Susanne Staaf, had to pick the right business model to commercialize their novel technology to hospitals and health care providers. Developed in...
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Keywords:
Health Care and Treatment;
Entrepreneurship;
Leadership;
Science-Based Business;
Growth and Development Strategy;
Business Growth and Maturation;
Business Model;
Technology;
Medical Devices and Supplies Industry;
Medical Devices and Supplies Industry;
Medical Devices and Supplies Industry;
Europe;
Sweden
- Article
Assessing the Food and Drug Administration's Risk-Based Framework for Software Precertification with Top Health Apps in the United States: Quality Improvement Study
By: Noy Alon, Ariel Dora Stern and John Torous
BACKGROUND: As the development of mobile health apps continues to accelerate, the need to implement a framework that can standardize categorizing these apps to allow for efficient, yet robust regulation grows. However, regulators and researchers are faced with numerous...
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- 2021
- Working Paper
Cephalosporins: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant Datar and Katherine Stebbins
Our case history describes the development of three generations of cephalosporins—antibiotics that have significantly reduced hospital infections. After providing an overview of antibiotic development and its challenges we describe how: 1) Early (pre-cephalosporin)...
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- 2021
- Working Paper
SSRIs and Non-SSRIs (through 1999): Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Our case history describes the development of Prozac, a blockbuster drug that transformed the treatment of depression – and became a cultural phenomenon in the United States. Specifically, we chronicle the: 1) prior treatments for depression and the research that...
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- Article
Treatment Of Opioid Use Disorder Among Commercially Insured U.S. Adults, 2008–17
By: Karen Shen, Eric Barrette and Leemore S. Dafny
There is abundant literature on efforts to reduce opioid prescriptions and misuse, but comparatively little on the treatment provided to people with opioid use disorder (OUD). Using claims data representing 12–15 million nonelderly adults covered through commercial...
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- April 29, 2020
- Article
How Should We Allocate Scarce Medical Resources?
By: Max Bazerman, Regan Bernhard, Joshua D. Greene, Karen Huang and Netta Barak-Corren
Who should get a ventilator if there aren’t enough to go around? Research on decision making leads to three concrete guidelines that policy-makers and physicians can use to make fair choices when allocating scarce, life-saving resources. The key to making fair and...
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Keywords:
COVID-19;
Health Pandemics;
Resource Allocation;
Decision Making;
Policy;
Fairness;
Ethics
- 2020
- Working Paper
Engineering Serendipity: When Does Knowledge Sharing Lead to Knowledge Production?
By: Jacqueline N. Lane, Ina Ganguli, Patrick Gaule, Eva C. Guinan and Karim R. Lakhani
We investigate how knowledge similarity between two individuals is systematically related to the likelihood that a serendipitous encounter results in knowledge production. We conduct a natural field experiment at a medical research symposium, where we exogenously...
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- 2021
- Working Paper
Eradicating Helicobacter Pylori Infections to Treat Ulcers: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
We describe how a chance discovery of bacteria that infect stomach linings completely changed how physicians treat ulcers. Specifically, we chronicle how: 1) two Australian physicians brought the bacterial infection to the world’s attention and challenged the...
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- 2021
- Working Paper
HIV Tests and AIDS Treatments: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
We describe how a diverse cast of characters including public health organizations, research laboratories, for-profit health care companies, activists and regulators, rolled back the outbreak of HIV/AIDS in just fifteen years. Moreover, as the case history shows, a...
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- 2021
- Working Paper
Who Do We Invent for? Patents by Women Focus More on Women's Health, but Few Women Get to Invent
By: Rembrand Koning, Sampsa Samila and John-Paul Ferguson
Has the increase in female medical researchers led to more medical advances for women? In this paper, we investigate if the gender of inventors shapes their types of inventions. Using data on the universe of U.S. biomedical patents, we find that patents with women...
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Keywords:
Innovation;
Biomedical Research;
Innovation and Invention;
Diversity;
Gender;
Research;
Health;
United States