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  • January 2023
  • Case

Cleave Therapeutics: Taking a Risk on Oncology Drug Discovery
By: Regina Herzlinger and Brian Walker
How can a successful executive assess her next move as the CEO of a firm with a promising and yet uncertain new drug? Amy Burroughs’ mandate to find a therapeutic window for Cleave Therapeutics oncology drug was on track but faced an uncertain future. Overseeing the...  View Details
Keywords: Product Development; Leadership; Health Testing and Trials; Research and Development; Risk and Uncertainty; Financial Condition; Partners and Partnerships; Pharmaceutical Industry
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  • September 17, 2020
  • Article

Protecting Vulnerable Older Patients during the Pandemic
By: Umar Ikram, Susanna Gallani, Jose F. Figueroa and Thomas W. Feeley
Older people (70 years and older) with multiple chronic conditions have the highest risk of being hospitalized and dying from COVID-19. The recent COVID-19 pandemic has highlighted how a strong primary care system can play an important role in protecting this group of...  View Details
Keywords: COVID-19; High-risk Patients; Primary Care; Health Pandemics; Health Care and Treatment; Innovation and Invention; Demographics; Age
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  • Article

Navy Medicine Introduces Value-Based Health Care
By: Alee Hernandez, Robert S. Kaplan, Mary L. Witkowski, C. Forrest Faison III and Michael E. Porter
In 2016 the newly appointed surgeon general of the Navy launched a value-based health care pilot project at Naval Hospital Jacksonville to explore whether multidisciplinary care teams (known as integrated practice units, or IPUs) and measurement of outcomes could...  View Details
Keywords: Military Health System; Health Care and Treatment; Cost Management; Projects
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  • January 2018
  • Article

The Central and Unacknowledged Role of the U.S. Food and Drug Administration in the Design and Execution of Medical Device Pivotal Trials
By: Aaron V. Kaplan and Ariel D. Stern
The introduction of new medical devices has transformed cardiovascular care in recent decades. Devices, such as heart valves, pacemakers, stents, ventricular assist devices, and implantable defibrillators, have prolonged and improved the quality of life for millions of...  View Details
Keywords: Health Testing and Trials; Business and Government Relations; Governing Rules, Regulations, and Reforms; Information Publishing; Medical Devices and Supplies Industry; United States
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