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- June 2021
- Technical Note
Introduction to Linear Regression
By: Michael Parzen and Paul J. Hamilton
This technical note introduces (from an applied point of view) the theory and application of simple and multiple linear regression. The motivation for the model is introduced, as well as how to interpret the summary output with regard to prediction and statistical...
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- May 2021
- Article
Risk-Mitigating Technologies: The Case of Radiation Diagnostic Devices
By: Alberto Galasso and Hong Luo
We study the impact of consumers’ risk perception on firm innovation. Our analysis exploits a major surge in the perceived risk of radiation diagnostic devices following extensive media coverage of a set of over-radiation accidents involving CT scanners in late 2009....
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- 2021
- Working Paper
Diagnosing Quality: Learning, Amenities, and the Demand for Health Care
By: Achyuta Adhvaryu, Emilio Gutierrez, Anant Nyshadham and Jorge Tamayo
We study the role of amenities in increasing demand for underutilized healthcare services. We evaluate the offer of a high-amenity diagnostic consultation for cataracts with a randomized price and find that a lower price for the high-amenity consultation increases...
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- 2021
- Working Paper
Real Credit Cycles
By: Pedro Bordalo, Nicola Gennaioli, Andrei Shleifer and Stephen J. Terry
We incorporate diagnostic expectations, a psychologically founded model of overreaction to news, into a workhorse business cycle model with heterogeneous firms and risky debt. A realistic degree of diagnosticity, estimated from the forecast errors of managers of U.S....
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- December 2020 (Revised April 2021)
- Case
IBM Watson at MD Anderson Cancer Center
By: Shane Greenstein, Mel Martin and Sarkis Agaian
After discovering that their cancer diagnostic tool, designed to leverage the cloud computing power of IBM Watson, needed greater integration into the clinical processes at the MD Anderson Cancer Center, the development team had difficult choices to make. The Oncology...
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Keywords:
Decision Making;
Innovation Strategy;
Knowledge Management;
Knowledge Use and Leverage;
Operations;
Failure;
Technology;
Information Technology;
Software;
Health Care and Treatment;
Product Development;
Health Industry;
Information Technology Industry;
Technology Industry;
United States;
Houston;
Texas
- November 2020 (Revised May 2021)
- Technical Note
Tales of Life-changing Innovations: Safe and Cheap Diagnostics | Note on the Development of Ultrasound Scanning (through 2000)
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
- October 2020
- Technical Note
Organizational Reinvention
By: Ryan Raffaelli
This note is designed to introduce students to the fundamental concepts of leading innovation in established organizations. Reinvention is a process whereby organizations respond to changes in the environment that threaten their core business model, technologies,...
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- August 2020 (Revised October 2020)
- Case
1928 Diagnostics: Fighting Antibiotics Resistance
By: Ariel D. Stern and Daniela Beyersdorfer
In 2019, the co-founders of the Swedish medical start-up 1928 Diagnostics, CEO Dr. Kristina Lagerstedt and COO Dr. Susanne Staaf, had to pick the right business model to commercialize their novel technology to hospitals and health care providers. Developed in...
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- Article
Assessing the Training Costs and Work of Diagnostic Radiology Residents Using Key Performance Indicators—An Observational Study
By: Robert S. Kaplan, Marta E. Heilbrun, Brad Poss, Luca Boi, Yoshimi Anzai and Nan Hu
- Article
Development of a Deep Learning Algorithm for Periapical Disease Detection in Dental Radiographs
By: Michael G. Endres, Florian Hillen, Marios Salloumis, Ahmad R. Sedaghat, Stefan M. Niehues, Olivia Quatela, Henning Hanken, Ralf Smeets, Benedicta Beck-Broichsitter, Carsten Rendenbach, Karim R. Lakhani, Max Helland and Robert A. Gaudin
Periapical radiolucencies, which can be detected on panoramic radiographs, are one of the most common radiographic findings in dentistry and have a differential diagnosis including infections, granuloma, cysts, and tumors. In this study, we seek to investigate the...
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- March 2020
- Article
Diagnosing Missing Always at Random in Multivariate Data
By: Iavor I. Bojinov, Natesh S. Pillai and Donald B. Rubin
Models for analyzing multivariate data sets with missing values require strong, often assessable, assumptions. The most common of these is that the mechanism that created the missing data is ignorable—a twofold assumption dependent on the mode of inference. The first...
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- 2020
- Article
Towards Modeling the Variability of Human Attention
By: Kuno Kim, Megumi Sano, Julian De Freitas, Daniel Yamins and Nick Haber
Children exhibit extraordinary exploratory behaviors hypothesized to contribute to the
building of models of their world. Harnessing this capacity in artificial systems promises
not only more flexible technology but also cognitive models of the...
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- 2021
- Working Paper
Computed Tomography: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
We describe how Computed Tomography (CT) scanners—that combine x-rays and computers to image soft tissues of the brain and other organs—have become a widely used diagnostic tool. Specifically, we chronicle the: 1) the initial development of CT technology and markets...
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- 2021
- Working Paper
Development of Ultrasound Scanning: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
We describe how efforts on multiple fronts, including advocacy, training and technological development made ultrasound the second most used diagnostic imaging technology (after X-rays). Specifically, we chronicle: 1) ultrasound’s development and introduction in the...
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- 2021
- Working Paper
Gastrointestinal Endoscopy: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
We describe how endoscopy transformed the diagnosis of ulcers, cancerous polyps and other diseases of the alimentary canal and enabled “minimally invasive” surgeries to treat such diseases. Specifically, we chronicle how: 1) flexible glass fiber instruments in the...
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- 2021
- Working Paper
Magnetic Resonance Imaging: Case Histories of Significant Medical Advances
By: Srikant M. Datar, Amar Bhidé and Katherine Stebbins
We describe how and why Magnetic Resource Imaging (MRI) came to complement – and partially replace -- computed tomography (CT) imaging of soft tissue. Specifically we chronicle: 1) the development of foundational techniques and prototypes (through the 1970s); 2)...
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- 2019
- Chapter
Characterizing the Drug Development Pipeline for Precision Medicines
By: Amitabh Chandra, Craig Garthwaite and Ariel Dora Stern
BOOK ABSTRACT: Personalized and precision medicine (PPM)—the targeting of therapies according to an individual’s genetic, environmental, or lifestyle characteristics—is becoming an increasingly important approach in health care treatment and prevention. The advancement...
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- 2018
- Working Paper
Diagnostic Bubbles
By: Pedro Bordalo, Nicola Gennaioli, Spencer Yongwook Kwon and Andrei Shleifer
We introduce diagnostic expectations into a standard setting of price formation in which investors learn about the fundamental value of an asset and trade it. We study the interaction of diagnostic expectations with two well-known mechanisms: learning from prices and...
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- February 2018
- Article
Diagnostic Expectations and Credit Cycles
By: Pedro Bordalo, Nicola Gennaioli and Andrei Shleifer
- Article
Stop the Meeting Madness: How to Free Up Time for Meaningful Work
By: Leslie Perlow, Constance Noonan Hadley and Eunice Eun
Many executives feel overwhelmed by meetings, and no wonder: On average, they spend nearly 23 hours a week in them, up from less than 10 hours in the 1960s. What’s more, the meetings are often poorly timed, badly run, or both. We can all joke about how painful they...
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