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- 2020
- Working Paper
Chimeric Antigen Receptor (CAR) T-Cell Therapy: Case Histories of Significant Medical Advances
By: Amar Bhidé and Srikant M. Datar
In 2017, the US Food and Drug Administration (FDA) approved an immunotherapeutic treatment, called CAR-T therapy, for two kinds of blood cancers—acute leukemia (ALL) and a lymphoma. We describe 1) how CAR-T works; 2) the foundational advances and discoveries; 3)...
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- September 2020
- Case
Minerva 2004: Discovery
By: John R. Wells and Benjamin Weinstock
After nearly five years in operation, Doctor Cynthia Bamdad, founder and CEO of Minerva Biotechnologies Corporation (Minerva), was reflecting on the company’s next steps. In a few short years, she and her small team had managed to develop a nanoparticle process for...
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- September 2020
- Case
Minerva 2020: Clinical Trials
By: John R. Wells and Benjamin Weinstock
In March 2020, Dr. Cynthia Bamdad, founder and CEO of Minerva Biotechnologies Inc. (Minerva), was reviewing the first results of human clinical trials for the company’s novel CAR-T drug therapeutic, one of the first ever to target solid cancer tumors. The results...
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- 2020
- Working Paper
Tamoxifen: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant Datar and Katherine Stebbins
Our case history describes the development of tamoxifen, considered a “gold standard” treatment for millions of breast cancer patients. Specifically, we describe breast cancer treatments prior to tamoxifen’s development; the initial development of tamoxifen from 1960...
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- December 2019
- Technical Note
Technical Note on Bayesian Statistics and Frequentist Power Calculations
By: Amitabh Chandra and Ariel Dora Stern
This Technical Note provides an introduction to Bayes’ Rule and the statistical intuition that stems from it. In this note, we review the concepts that underlie Bayesian statistics, and we offer several simple mathematical examples to illustrate applications of Bayes’...
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- November 2019 (Revised December 2019)
- Case
Martini Klinik: Prostate Cancer Care 2019
By: Michael E. Porter, Jens Deerberg-Wittram and Thomas W. Feeley
Since its establishment in 2005, Hamburg’s Martini Klinik had single mindedly focused on prostate cancer care with a commitment to measure long-term health outcomes for every patient. A wholly owned subsidiary of the University Hospital Hamburg, Martini Klinik was a...
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Keywords:
Health Care;
Michael Porter;
Jens Deerberg-wittram;
Clifford Marks;
Prostate Cancer;
Health Care Policy;
Value Agenda;
Integrated Practice Units;
Outcomes Measurement;
Health Care and Treatment;
Value;
Health Disorders;
Insurance;
Medical Specialties;
Outcome or Result;
Measurement and Metrics;
Business Processes;
Insurance Industry;
Health Industry;
Germany
- Article
Use of Crowd Innovation to Develop an Artificial Intelligence-Based Solution for Radiation Therapy Targeting
By: Raymond H. Mak, Michael G. Endres, Jin Hyun Paik, Rinat A. Sergeev, Hugo Aerts, Christopher L. Williams, Karim R. Lakhani and Eva C. Guinan
Importance: Radiation therapy (RT) is a critical cancer treatment, but the existing radiation oncologist work force does not meet growing global demand. One key physician task in RT planning involves tumor segmentation for targeting, which requires substantial...
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- February 2019 (Revised October 2019)
- Case
Extend Fertility: Conceiving the Market for Egg Preservation (A)
By: Debora L. Spar and Olivia Hull
In April 2003, entrepreneur and MBA student Christy Jones was planning a new venture to help women preserve their fertility. Her company, Extend Fertility, would commercialize a technique known as egg freezing, in which a woman’s eggs were extracted and stored at low...
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- November 12, 2018
- Article
Precision Medicine Has Transformed Cancer Treatment. Here's How to Move It Beyond Oncology
By: Richard G. Hamermesh and Kathy Giusti
- November 2018
- Case
David Hysong and SHEPHERD Therapeutics
By: Ananth Raman, John Masko and Aldo Sesia
In 2016, David Hysong, at age 27, found out he had a rare, incurable cancer. Rather than wait around to die, Hysong, a recent graduate of Harvard Divinity School, decided to launch a biotechnology company called Shepherd Therapeutics to development treatments for his...
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- February 2018
- Article
Development and Feasibility of Bundled Payments for the Multidisciplinary Treatment of Head and Neck Cancer: A Pilot Program
By: Tracy Spinks, Alexis Guzman, Beth M. Beadle, Seohyun Lee, Ron Walters, Jim Incalcaterra, Ehab Hanna, Amy Hessel, Randal Weber, Sandra Denney, Lee Newcomer and Thomas W. Feeley
Purpose:
Despite growing interest in bundled payments to reduce the costs of care, this payment method remains largely untested in cancer. This 3-year pilot tested the feasibility of a 1-year bundled payment for the multidisciplinary treatment of head and neck...
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- November 2017
- Article
A Retrospective Analysis of Hypertension Screening at a Mass Gathering in India: Implications for Non-communicable Disease Control Strategies
By: S. Balsari, P. Vemulapalli, M. Gofine, K. Oswal, R. Merchant, S. Saunik, G. Greenough and T. Khanna
Cardiovascular disease is the leading cause of mortality from noncommunicable diseases (NCD) in India. The government’s National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke seeks to increase capacity building, screening,...
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- September 2017 (Revised December 2017)
- Case
Intermountain Healthcare: Pursuing Precision Medicine
By: Richard G. Hamermesh, Kathy E. Giusti, Robert S. Huckman and Julia Kelley
Headquartered in Salt Lake City, Intermountain Healthcare operates 23 hospitals and hundreds of clinics in Utah and Idaho and provides insurance to approximately 850,000 patients through its insurance arm, SelectHealth. In 2013, Intermountain, known for its commitment...
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- September 2016
- Article
Communicating Value in Healthcare Using Radar Charts: A Case Study of Prostate Cancer
By: Nikhil G. Thaker, Tariq N. Ali, Michael E. Porter, Thomas W. Feeley, Robert S. Kaplan and Steven J. Frank
Question: Can we create a value-based tool to visualize the outcomes and cost of various treatments that could facilitate patient-centered decision making?
Summary Answer: We developed a standardized value framework by using radar charts to visualize and... View Details
Summary Answer: We developed a standardized value framework by using radar charts to visualize and... View Details
- August 2016
- Article
Value-Based Breast Cancer Care: A Multidisciplinary Approach for Defining Patient-Centered Outcomes
By: Fayanju M. Oluwadamilola, Tinisha L. Mayo, Tracy E. Spinks, Seohyun Lee, Carlos H. Barcenas, Benjamin D. Smith, Sharon H. Giordano, Rosa F. Hwang, Richard A. Ehlers, Jesse C. Selber, Ronald Walters, Debu Tripathy, Kelly K. Hunt, Thomas A. Buchholz, Thomas W. Feeley and Henry M. Kuerer
Purpose. Value in healthcare—i.e., patient-centered outcomes achieved per healthcare dollar spent—can define quality and unify performance improvement goals with health outcomes of importance to patients across the entire cycle of care. We describe the process...
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- Article
Defining the Value Framework for Prostate Brachytherapy Using Patient-Centered Outcome Metrics and Time-Driven Activity-Based Costing
By: N.G. Thaker, T.J. Pugh, U. Mahmood, S. Choi, T.E. Spinks, N.E. Martin, T.T. Sio, R.J. Kudchadker, R. S. Kaplan, D.A. Kuban, D.A. Swanson, P.F. Orio, M.J. Zelefsky, B.W. Cox, L. Potters, T.A. Buchholz, T.W. Feeley and S.J. Frank
PURPOSE:
Value, defined as outcomes over costs, has been proposed as a measure to evaluate prostate cancer (PCa) treatments. We analyzed standardized outcomes and time-driven activity-based costing (TDABC) for prostate brachytherapy (PBT) to define a value...
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- July 2014
- Article
Second-Opinion Pathologic Review is a Patient Safety Mechanism That Helps Reduce Error and Decrease Waste
By: Lavinia Middleton, Thomas W. Feeley, Heidi W. Albright, Ronald Walters and Stanley Hamilton
We have a crisis in health care delivery, originating from increasing health care costs and inconsistent quality-of-care measures. During the past several years, value-based health care delivery has gained increasing attention as an approach to control costs and...
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- May 2014
- Case
Health Care Accountability: Examples in Cancer Treatment
By: Regina E. Herzlinger and Natalie Kindred
This case is designed to support a discussion of the importance of outcomes evidence in empowering the public to make better health care decisions, the desired level of transparency and accountability for health care providers, and the issues with current measuring and...
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Keywords:
Accountability;
Health Care;
Cancer;
Cancer Treatment;
Memorial Sloan Kettering Cancer Center;
Cancer Treatment Centers Of America;
Vantage Oncology;
Radiology;
Risk Adjustment;
Treatment Outcomes;
Health Care Outcomes;
Prostate Cancer;
Transparency;
Health Care and Treatment;
Risk Management;
Outcome or Result;
Health Industry;
United States
- March 2014 (Revised June 2014)
- Case
Martini Klinik: Prostate Cancer Care
By: Michael E. Porter, Jens Deerberg-Wittram, Thomas W. Feeley and Clifford M. Marks
Since its establishment in 2005, Hamburg's Martini Klinik had single-mindedly focused on prostate cancer care with a commitment to measure long-term health outcomes for every patient. A wholly owned subsidiary of the Hamburg University Hospital, Martini was a "hospital...
View Details
Keywords:
Health Care;
Germany;
Michael Porter;
Jens Deerberg-wittram;
Clifford Marks;
Prostate Cancer;
Health Care Policy;
Value Agenda;
Integrated Practice Units;
Outcomes Measurement;
Value;
Health Disorders;
Insurance;
Medical Specialties;
Outcome or Result;
Business Processes;
Insurance Industry;
Health Industry;
Germany
- March 2014 (Revised September 2014)
- Supplement
Cancer Treatment Centers of America® (B)
By: Regina E. Herzlinger and Natalie Kindred
This case, a follow-up to Cancer Treatment Centers of America (A), HBS No. 313-012, begins with the debate over New Hampshire's certificate-of-need (CON) law, which restricts hospital expansion. This debate ignited significant public criticism of Cancer Treatment...
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Keywords:
Cancer;
Cancer Treatment;
Accountability;
Outcomes;
Outcomes Reporting;
Outcomes Measurement;
Survival;
For-profit Hospitals;
Health Care;
Healthcare;
Hospital;
Certificate Of Need;
Health Care and Treatment;
Outcome or Result;
Corporate Accountability;
Policy;
Health Industry;
United States