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      • Faculty Publications  (42)

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      • April 18, 2022
      • Article

      Will mRNA Technology Companies Spawn Innovation Ecosystems?

      By: Christoph Grimpe, Timo Minssen, W. Nicholson Price, II and Ariel Dora Stern
      The mRNA technologies that helped rapidly create effective COVID-19 vaccines could become technology platform businesses, which has tremendous implications for players in the world of drug development. These platforms could attract other companies interested in...  View Details
      Keywords: Health Care; Digital Health; Technology; Innovation; Health Care and Treatment; Technological Innovation; Digital Transformation; Health Industry; United States
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      Grimpe, Christoph, Timo Minssen, W. Nicholson Price, II, and Ariel Dora Stern. "Will mRNA Technology Companies Spawn Innovation Ecosystems?" Harvard Business Review (website) (April 18, 2022).
      • February 2022
      • Case

      Leading The UK Vaccine Task Force

      By: Amy C. Edmondson and Claudia Pienica
      This case describes the first six months of the UK Vaccine Taskforce, under the leadership of Kate Bingham. With a career spent in the private sector as a biotech investor, Bingham’s appointment within the government was considered unusual. The overarching brief given...  View Details
      Keywords: COVID-19; Vaccine; Government; Health Pandemics; Health Care and Treatment; Science; Innovation and Invention; Groups and Teams; Leadership; Decision Making; Government and Politics; Health; Innovation and Management; Governance; Change; Government Administration; Health Industry; Financial Services Industry; Public Administration Industry; Europe; United Kingdom
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      Edmondson, Amy C., and Claudia Pienica. "Leading The UK Vaccine Task Force." Harvard Business School Case 622-079, February 2022.
      • June 2021
      • Case

      uBiome

      By: Thomas R. Eisenmann and Olivia Graham
      uBiome provided clinical tests that sequenced the DNA of human microbiome samples, providing data on health conditions directly to consumers or to prescribing physicians. Founded in 2012, the San Francisco-based startup raised $105 million from top-tier venture capital...  View Details
      Keywords: Business Startups; Crime and Corruption; Insolvency and Bankruptcy
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      Eisenmann, Thomas R., and Olivia Graham. "uBiome." Harvard Business School Case 821-076, June 2021.
      • January 2021
      • Case

      Takeda Pharmaceutical Company Limited (A)

      By: David J. Collis, Nobuo Sato and Akiko Kanno
      This case follows Christophe Weber, President and CEO of Takeda Pharmaceutical Company Limited, a leading pharmaceutical company headquartered in Tokyo, Japan, as Takeda considers acquiring Shire Plc, a biotech company based in Ireland. The acquisition would turn...  View Details
      Keywords: Pharmaceutical Companies; Pharmaceuticals; Biotech; Biotechnology; M&A; Mergers & Acquisitions; R&D; Talent Management; Mergers and Acquisitions; Globalization; Management; Global Strategy; Talent and Talent Management; Pharmaceutical Industry; Biotechnology Industry; Japan; Asia
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      Collis, David J., Nobuo Sato, and Akiko Kanno. "Takeda Pharmaceutical Company Limited (A)." Harvard Business School Case 721-373, January 2021.
      • January 2021
      • Supplement

      Takeda Pharmaceutical Company Limited (B)

      By: David J. Collis, Nobuo Sato and Akiko Kanno
      This case is a follow up to HBS Case No. 721-373, Takeda Pharmaceutical Company Limited (A). Following the events of the previous case, Takeda reached an agreement to acquire Ireland-based Shire Plc. The case follows some of the achievements and challenges Takeda and...  View Details
      Keywords: Pharmaceutical Companies; Pharmaceuticals; M&A; Mergers & Acquisitions; Biotech; Biotechnology; R&D; Talent Management; Mergers and Acquisitions; Globalization; Global Strategy; Talent and Talent Management; Strategy; Biotechnology Industry; Pharmaceutical Industry; Japan; Asia
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      Collis, David J., Nobuo Sato, and Akiko Kanno. "Takeda Pharmaceutical Company Limited (B)." Harvard Business School Supplement 721-374, January 2021.
      • September 2020 (Revised July 2021)
      • Case

      Moderna (A)

      By: Marco Iansiti, Karim R. Lakhani, Hannah Mayer and Kerry Herman
      In summer 2020, Stephane Bancel, CEO of biotech firm Moderna, faces several challenges as his company races to develop a vaccine for COVID-19. The case explores how a company builds a digital organization, and leverages artificial intelligence and other digital...  View Details
      Keywords: COVID-19; Vaccine; Digital Organizations; Organizational Structure; Operations; Management; Health Pandemics; Research and Development; Goals and Objectives
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      Iansiti, Marco, Karim R. Lakhani, Hannah Mayer, and Kerry Herman. "Moderna (A)." Harvard Business School Case 621-032, September 2020. (Revised July 2021.)
      • September 2020 (Revised January 2021)
      • Case

      Catalys Pacific

      By: Joshua Lev Krieger
      In 2019, BT Slingsby founds Catalys Pacific, the first biotech “venture creation” fund in Tokyo. After convincing some of the biggest Japanese pharmaceutical firms to invest, BT hopes the fund can make a big splash and transform biotechnology innovation in Japan. After...  View Details
      Keywords: Pharmaceutical Companies; Biotech; Health Care; Entrepreneur; Innovation; International Business; Entrepreneurial Finance; Entrepreneurship; Finance; Innovation Strategy; Venture Capital; Strategy; Cross-Cultural and Cross-Border Issues; Pharmaceutical Industry; Biotechnology Industry; Tokyo
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      Krieger, Joshua Lev. "Catalys Pacific." Harvard Business School Case 821-035, September 2020. (Revised January 2021.)
      • October 2019
      • Case

      Kymera Therapeutics: Building a Biotech Execution Plan

      By: Peter Barrett, Karim R. Lakhani and Kerry Herman
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      Barrett, Peter, Karim R. Lakhani, and Kerry Herman. "Kymera Therapeutics: Building a Biotech Execution Plan." Harvard Business School Case 620-017, October 2019.
      • June 2018
      • Teaching Note

      Sandra Brown Goes Digital

      By: Rosabeth Moss Kanter and Jonathan Cohen
      As a middle manager at a biotechnology company, Sandra Brown harnessed digital tools and social media to engage others and build campaigns for change in the company. This Teaching Note presents strategies for teaching the Sandra Brown case series, which follows Brown's...  View Details
      Keywords: Change Leadership; Change Management; Digital; Engagement; Stakeholder Engagement; Grassroots Movement; Health Care Industry; Career Path; Innovation; Leading Change; Management; Innovation and Management; Personal Development and Career; Organizational Change and Adaptation; Quality
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      Kanter, Rosabeth Moss, and Jonathan Cohen. "Sandra Brown Goes Digital." Harvard Business School Teaching Note 318-156, June 2018.
      • March 2018 (Revised July 2018)
      • Case

      GreenLight Biosciences: In Search of Impact Investment

      By: Michael Chu, Annelena Lobb and Joni Coughlin
      Greenlight Biosciences, a biotech company, is in search of impact investment for its next round of financing.  View Details
      Keywords: Impact Investment; Investment; Environmental Sustainability; Financing and Loans; Biotechnology Industry
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      Chu, Michael, Annelena Lobb, and Joni Coughlin. "GreenLight Biosciences: In Search of Impact Investment." Harvard Business School Case 318-072, March 2018. (Revised July 2018.)
      • March 2018
      • Supplement

      Sandra Brown Goes Digital (B): The Commitment Decision

      By: Rosabeth Moss Kanter and Jonathan Cohen
      Sandra Brown, a middle manager at a biotech company who has led internal and external movements for change over the last few years, faces a decision. Whether to continue to work for change at the company or move on to pursue new opportunities elsewhere, where her new...  View Details
      Keywords: Digital; Stakeholder Engagement; Managing Change; Career Path; Health Care Industry; Quality; Leading Change; Management; Organizational Change and Adaptation; Personal Development and Career; Decision Choices and Conditions
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      Kanter, Rosabeth Moss, and Jonathan Cohen. "Sandra Brown Goes Digital (B): The Commitment Decision." Harvard Business School Supplement 318-083, March 2018.
      • March 2018
      • Supplement

      Sandra Brown Goes Digital (C): Raising Quality in a Healthcare Company

      By: Rosabeth Moss Kanter and Jonathan Cohen
      Using digital and social media tools and lessons learned from prior change campaigns as a middle manager in a large biotech company, Sandra Brown continued in a new role in the quality division, engaging staff in a quality movement at the company. She had found a new...  View Details
      Keywords: Digital; Grassroots Movement; Managing Change; Career Path; Stakeholder Engagement; Engagement; Health Care Industry; Quality; Leading Change; Performance Improvement; Personal Development and Career; Social Media; Health Industry
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      Kanter, Rosabeth Moss, and Jonathan Cohen. "Sandra Brown Goes Digital (C): Raising Quality in a Healthcare Company." Harvard Business School Supplement 318-084, March 2018.
      • November 2016
      • Supplement

      Alnylam Pharmaceuticals: Building Value from the IP Estate (B)

      By: Vicki Sato, Willy Shih and Matt Higgins
      The leader of a pioneering biotech company in the siRNA space weighs his options for scaling production capacity in advance of an anticipated commercial launch. Operational complexity and relative merits of in-house manufacturing versus a contractor model are...  View Details
      Keywords: Pharmaceutical Companies; Pharmaceutical Industry; Biotech; Biotechnology; Operational Complexity; Strategy; Manufacturing; Production; Strategic Planning; Intellectual Property; Biotechnology Industry; United States
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      Sato, Vicki, Willy Shih, and Matt Higgins. "Alnylam Pharmaceuticals: Building Value from the IP Estate (B)." Harvard Business School Supplement 617-022, November 2016.
      • November 2016
      • Case

      Anthony Starks at InSiL Therapeutics (A)

      By: Gary Pisano and Vicki Sato
      When Bruce Wayne hired Anthony Starks, he thought he had hit a home run by getting the most brilliant and passionate scientist-leader in the field to be his CSO. But a few months in, Wayne and Starks begin to clash over crucial forward-looking decisions about the...  View Details
      Keywords: Biotech; Silicon; Managing Innovation; Management Challenges; Managing People; Managing Organization; R&D; R&D Project Management; Platform; Venture Capital; Drug Discovery; management; Biotechnology Industry; California
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      Pisano, Gary, and Vicki Sato. "Anthony Starks at InSiL Therapeutics (A)." Harvard Business School Case 617-029, November 2016.
      • November 2016 (Revised December 2016)
      • Supplement

      Anthony Starks at InSiL Therapeutics (B)

      By: Vicki Sato and Gary Pisano
      This case accompanies the (A) case from Anthony Starks's perspective.  View Details
      Keywords: Biotech; Management Challenges; R&D; R&D Project Management; Management; Biotechnology Industry; California
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      Sato, Vicki, and Gary Pisano. "Anthony Starks at InSiL Therapeutics (B)." Harvard Business School Supplement 617-030, November 2016. (Revised December 2016.)
      • November 2016
      • Case

      QuintilesIMS: Biosimilar Marketing in England

      By: John A. Quelch and Emily C. Boudreau
      QuintilesIMS was a leading healthcare consulting firm best known for its data and information offerings as well as its market research and management consulting services for life science companies. By 2015, the company was expanding beyond the biopharmaceutical...  View Details
      Keywords: Health; Pharmaceutical Industry; Biotech; Marketing; Health Care and Treatment; Biotechnology Industry; England
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      Quelch, John A., and Emily C. Boudreau. "QuintilesIMS: Biosimilar Marketing in England." Harvard Business School Case 517-054, November 2016.
      • June 2014 (Revised February 2017)
      • Case

      Kathy Giusti and the Multiple Myeloma Research Foundation

      By: Richard G. Hamermesh, Joshua D. Margolis and Matthew G. Preble
      What do you do when your rising professional career is cut short by an unexpected cancer diagnosis? Kathy Giusti shifted careers, built a new organization that transformed how cancer research is done, and now faces the challenge of sustaining the organization and its...  View Details
      Keywords: Philanthropy; Philanthropy Funding; Entrepreneurship; Health Care; Management Styles; Personalized Medicine; Health Care Outcomes; Cancer; Cancer Care In The U.S.; Personal Care; Leadership; Leading Change; Social Entrepreneurship; Philanthropy and Charitable Giving; Health Care and Treatment; Leadership Style; Management Style; Management Skills; Growth and Development Strategy; Business Strategy; Health; Health Industry; United States; Canada; Spain
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      Hamermesh, Richard G., Joshua D. Margolis, and Matthew G. Preble. "Kathy Giusti and the Multiple Myeloma Research Foundation." Harvard Business School Case 814-026, June 2014. (Revised February 2017.)
      • January 2014
      • Supplement

      Fred Khosravi and AccessClosure (C)

      By: Richard Hamermesh and Lauren Barley
      On September 11, 2013, the three-judge panel of the U.S. Court of Appeals for the Federal Circuit denied St. Jude's request to rehear an appeal on the "double patenting" ruling for the '439 patent. Further, it removed the injunction threat that was hanging over the...  View Details
      Keywords: Medical Devices; Vascular Closure Device; Patent Litigation; Patenting; Biomedical Research; Biotechnology; Biotech; Technological Innovation; Patents; Health Care and Treatment; Biotechnology Industry; United States
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      Hamermesh, Richard, and Lauren Barley. "Fred Khosravi and AccessClosure (C)." Harvard Business School Supplement 814-074, January 2014.
      • October 2013 (Revised January 2014)
      • Supplement

      Fred Khosravi and AccessClosure (B)

      By: Richard G. Hamermesh and Lauren Barley
      It was January 2013, and Fred Khosravi, chairman of the board of AccessClosure Inc., wondered what the new year had in store for him and AccessClosure, the company he founded in late 2002. Khosravi was cautiously optimistic—the Mountain View, California-based medical...  View Details
      Keywords: Medical Devices; Vascular Closure Device; Patent Litigation; Patenting; Biomedical Research; Biotechnology; Biotech; Technological Innovation; Patents; Health Care and Treatment; Biotechnology Industry; United States; California
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      Hamermesh, Richard G., and Lauren Barley. "Fred Khosravi and AccessClosure (B)." Harvard Business School Supplement 814-038, October 2013. (Revised January 2014.)
      • September 2013 (Revised November 2015)
      • Case

      Living Proof: Are We a Technology Company or a Beauty Company?

      By: Willy Shih

      Jon Flint came up with the idea of a science-based beauty company while talking with his hairdresser about the problems with typical hair and skin care products. Together with a small team that included Professor Robert Langer of MIT, he committed to assemble a team...  View Details

      Keywords: Hair Care; Personal Care; Science-based; R&D; Innovation and Invention; Innovation and Management; Innovation Leadership; Innovation Strategy; Technological Innovation; Marketing; Marketing Strategy; Product Marketing; Product Positioning; Science-Based Business; Business Strategy; Commercialization; Corporate Strategy; Technology Platform; Expansion; Beauty and Cosmetics Industry; United States; Boston; Cambridge
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      Shih, Willy. "Living Proof: Are We a Technology Company or a Beauty Company?" Harvard Business School Case 614-013, September 2013. (Revised November 2015.)
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