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- October 2022
- Case
Afrigen Biologics: Vaccines for the Global South
By: Debora L. Spar and Julia Comeau
The majority of vaccines used on the continent of Africa (99%) are produced offshore. This makes African nations reliant on the West for major health care needs, a problem which was exacerbated by the COVID-19 pandemic. Afrigen Biologics (in partnership with the WHO)... View Details
Keywords: Vaccination; Vaccine; mRNA; COVID; COVID-19; Inequity; Hub-and-spoke; Health Care and Treatment; Health Pandemics; Production; Social Issues; Business and Government Relations; South Africa; Africa
Spar, Debora L., and Julia Comeau. "Afrigen Biologics: Vaccines for the Global South." Harvard Business School Case 323-030, October 2022.
- 2021
- Working Paper
The Great Unequalizer: Initial Health Effects of COVID-19 in the United States
By: Marcella Alsan, Amitabh Chandra and Kosali I. Simon
We measure inequities from the COVID-19 pandemic on mortality and hospitalizations in the United States during the early months of the outbreak. We discuss challenges in measuring health outcomes and health inequality, some of which are specific to COVID-19 and others... View Details
Alsan, Marcella, Amitabh Chandra, and Kosali I. Simon. "The Great Unequalizer: Initial Health Effects of COVID-19 in the United States." NBER Working Paper Series, No. 28958, June 2021.
- 2020
- Working Paper
A General Theory of Identification
By: Iavor Bojinov and Guillaume Basse
What does it mean to say that a quantity is identifiable from the data? Statisticians seem to agree
on a definition in the context of parametric statistical models — roughly, a parameter θ in a model
P = {Pθ : θ ∈ Θ} is identifiable if the mapping θ 7→ Pθ is injective.... View Details
Bojinov, Iavor, and Guillaume Basse. "A General Theory of Identification." Harvard Business School Working Paper, No. 20-086, February 2020.
- September 2019 (Revised August 2020)
- Case
Engineering an Inclusive Bioeconomy
By: Tarun Khanna, Raffaella Sadun and Susie L. Ma
In 2019, entrepreneur Juan Carlos Castilla-Rubio was developing a project he hoped could generate and share wealth from the natural resources of the Amazon without destroying those resources. His idea, called Earth Bank of Codes (EBC), would create a library of the... View Details
Keywords: Decision Making; Development Economics; Entrepreneurship; Innovation and Invention; Intellectual Property; Emerging Markets; Market Design; Marketplace Matching; Science; Genetics; Natural Environment; Environmental Sustainability; Climate Change; Social Enterprise; Strategy; Strategic Planning; Information Technology; Ownership; Social Psychology; Trust; Society; Biotechnology Industry; South America; Amazon Basin
Khanna, Tarun, Raffaella Sadun, and Susie L. Ma. "Engineering an Inclusive Bioeconomy." Harvard Business School Case 720-356, September 2019. (Revised August 2020.)
- March 2019
- Article
Crime and Violence: Desensitization in Victims to Watching Criminal Events
By: Rafael Di Tella, Lucia Freira, Ramiro H. Gálvez, Ernesto Schargrodsky, Diego Shalom and Mariano Sigman
We study desensitization to crime in a lab experiment by showing footage of criminal acts to a group of subjects, some of whom have been previously victimized. We measure biological markers of stress and behavioral indices of cognitive control before and after treated... View Details
Keywords: Crime; Biological Markers; Experiment; Victimization; Desensitization; Crime and Corruption; Behavior
Di Tella, Rafael, Lucia Freira, Ramiro H. Gálvez, Ernesto Schargrodsky, Diego Shalom, and Mariano Sigman. "Crime and Violence: Desensitization in Victims to Watching Criminal Events." Journal of Economic Behavior & Organization 159 (March 2019): 613–625.
- December 2018 (Revised May 2019)
- Case
Darling Ingredients International
By: David E. Bell and Natalie Kindred
Led by CEO Randall Stuewe, Texas-based Darling Ingredients International was a rendering firm with $3.7 billion in 2017 revenues. Since 2003, Darling had transformed from U.S. focused into a global player in the processing of biological waste from meat and foodservice... View Details
Keywords: Darling; Ingredients; Stuewe; Rendering; Animal Byproducts; Used Cooking Oil; UCO; Diamond Green Diesel; DGD; Valero; Renewable Diesel; Biofuel; Recycling; Carbon; LCFS; Blend; Blender; Strategy; Corporate Strategy; Renewable Energy; Food; Agribusiness; Expansion; Diversification; Growth Management; Technological Innovation; Policy; Government Legislation; Agriculture and Agribusiness Industry; Energy Industry; Food and Beverage Industry; United States; Louisiana; California; Texas
Bell, David E., and Natalie Kindred. "Darling Ingredients International." Harvard Business School Case 519-048, December 2018. (Revised May 2019.)
- 2018
- Chapter
The Orphan Drug Act at 35: Observations and an Outlook for the Twenty-First Century
By: Nicholas Bagley, Benjamin Berger, Amitabh Chandra, Craig Garthwaite and Ariel Dora Stern
On the 35th anniversary of the adoption of the Orphan Drug Act (ODA), we describe the enormous changes in the markets for therapies for rare diseases that have emerged over recent decades. The most prominent example is the fact that the profit-maximizing price of new... View Details
Keywords: Health Care and Treatment; Laws and Statutes; Research and Development; Investment; Markets; Monopoly
Bagley, Nicholas, Benjamin Berger, Amitabh Chandra, Craig Garthwaite, and Ariel Dora Stern. "The Orphan Drug Act at 35: Observations and an Outlook for the Twenty-First Century." Chap. 4 in Innovation Policy and the Economy, Volume 19, edited by Josh Lerner and Scott Stern, 97–137. University of Chicago Press, 2018.
- March 2018 (Revised March 2019)
- Case
Gender and Free Speech at Google (A)
By: Nien-hê Hsieh, Martha J. Crawford and Sarah Mehta
In August 2017, Google fired James Damore, a 28-year-old software engineer who had been employed by the company since 2013. The move came after Damore penned an internal company memo titled “Google’s Ideological Echo Chamber,” which posited that innate biological... View Details
Keywords: Free Speech; Representation; Diversity; Gender; Race; Human Resources; Employees; Employee Relationship Management; Recruitment; Selection and Staffing; Labor; Employment; Lawsuits and Litigation; Organizational Culture; Technology Industry; United States; California
Hsieh, Nien-hê, Martha J. Crawford, and Sarah Mehta. "Gender and Free Speech at Google (A)." Harvard Business School Case 318-085, March 2018. (Revised March 2019.)
- 2017
- Working Paper
Crime and Violence: Desensitization in Victims to Watching Criminal Events
By: Rafael Di Tella, Lucía Freira, Ramiro H. Gálvez, Ernesto Schargrodsky, Diego Shalom and Mariano Sigman
We study desensitization to crime in a lab experiment by showing footage of criminal acts to a group of subjects, some of whom have been previously victimized. We measure biological markers of stress and behavioral indices of cognitive control before and after treated... View Details
Keywords: Crime; Biological Markers; Experiment; Victimization; Desensitization; Crime and Corruption; Perspective; Attitudes; Behavior
Di Tella, Rafael, Lucía Freira, Ramiro H. Gálvez, Ernesto Schargrodsky, Diego Shalom, and Mariano Sigman. "Crime and Violence: Desensitization in Victims to Watching Criminal Events." Harvard Business School Working Paper, No. 18-039, October 2017.
- 2017
- Working Paper
Crime and Violence: Desensitization in Victims to Watching Criminal Events
By: Rafael Di Tella, Lucia Freira, Ramiro H. Gálvez, Ernesto Schargrodsky, Diego Shalom and Mariano Sigman
We study desensitization to crime in a lab experiment by showing footage of criminal acts to a group of subjects, some of whom have been previously victimized. We measure biological markers of stress and behavioral indices of cognitive control before and after treated... View Details
Di Tella, Rafael, Lucia Freira, Ramiro H. Gálvez, Ernesto Schargrodsky, Diego Shalom, and Mariano Sigman. "Crime and Violence: Desensitization in Victims to Watching Criminal Events." NBER Working Paper Series, No. 23697, August 2017.
- November 2016
- Case
QuintilesIMS: Biosimilar Marketing in England
By: John A. Quelch and Emily C. Boudreau
QuintilesIMS was a leading healthcare consulting firm best known for its data and information offerings as well as its market research and management consulting services for life science companies. By 2015, the company was expanding beyond the biopharmaceutical... View Details
Keywords: Health; Pharmaceutical Industry; Biotech; Marketing; Health Care and Treatment; Biotechnology Industry; England
Quelch, John A., and Emily C. Boudreau. "QuintilesIMS: Biosimilar Marketing in England." Harvard Business School Case 517-054, November 2016.
- June 2016 (Revised August 2019)
- Case
Numenta: Inventing and (or) Commercializing AI
By: David B. Yoffie, Liz Kind and David Ben Shimol
In March 2016, Donna Dubinsky (co-founder and CEO) and Jeff Hawkins (co-founder) were struggling with a key question: Could Numenta be successful in both creating fundamental technology and building a commercial business? Located in Redwood City, CA, Numenta was... View Details
Keywords: Artificial Intelligence; Machine Intelligence; Machine Learning; Strategy; Business Model; Entrepreneurship; Information; Technological Innovation; Research; Research and Development; Information Technology; Applications and Software; Technology Adoption; Digital Platforms; Commercialization; AI and Machine Learning
Yoffie, David B., Liz Kind, and David Ben Shimol. "Numenta: Inventing and (or) Commercializing AI." Harvard Business School Case 716-469, June 2016. (Revised August 2019.)
- October 2015
- Article
Hormones and Ethics: Understanding the Biological Basis of Unethical Conduct
By: Jooa Julie Lee, Francesca Gino, Ellie Shuo Jin, Leslie K. Rice and Robert A. Josephs
Globally, fraud has been rising sharply over the last decade, with current estimates placing financial losses at greater than $3.7 trillion dollars annually. Unfortunately, fraud prevention has been stymied by lack of a clear and comprehensive understanding of its... View Details
Lee, Jooa Julie, Francesca Gino, Ellie Shuo Jin, Leslie K. Rice, and Robert A. Josephs. "Hormones and Ethics: Understanding the Biological Basis of Unethical Conduct." Journal of Experimental Psychology: General 144, no. 5 (October 2015): 891–897.
- Article
No Evidence for an Effect of Testosterone Administration on Delay Discounting in Male University Students
By: Georgia Rada Ortner, Matthias Wibral, Anke Becker, Thomas Dohmen, Dietrich Klingmüller, Armin Falk and Bernd Weber
Intertemporal choices between a smaller sooner and a larger delayed reward are one of the most important types of decisions humans face in their everyday life. The degree to which individuals discount delayed rewards correlates with impulsiveness. Steep delay... View Details
Keywords: Delay Discounting; Impulsiveness; Intertemporal Choice; Testosterone; Decision Making; Behavior; Personal Characteristics
Rada Ortner, Georgia, Matthias Wibral, Anke Becker, Thomas Dohmen, Dietrich Klingmüller, Armin Falk, and Bernd Weber. "No Evidence for an Effect of Testosterone Administration on Delay Discounting in Male University Students." Psychoneuroendocrinology 38, no. 9 (September 2013): 1814–1818.
- July 2011 (Revised January 2013)
- Case
Digital Microscopy Is Making Me Crazy!
By: Willy Shih
For Carl Zeiss Microimaging, modular hardware and software enabled customers to tailor Zeiss's broad range of microscopy systems hardware and software to meet a wide range of needs from basic scientific research in the biological and medical sciences to clinical... View Details
Keywords: Information Infrastructure; Applications and Software; Corporate Strategy; Disruptive Innovation; Science-Based Business; Management Analysis, Tools, and Techniques; Business Conglomerates; Digital Platforms; Opportunities; Medical Devices and Supplies Industry; Computer Industry
Shih, Willy. "Digital Microscopy Is Making Me Crazy!" Harvard Business School Case 612-002, July 2011. (Revised January 2013.)
- April 2011
- Teaching Note
Office of Technology Transfer - Shanghai Institutes for Biological Sciences (TN)
By: Willy Shih and Sen Chai
Teaching Note for 611057. View Details
- March 2011 (Revised June 2012)
- Case
Office of Technology Transfer - Shanghai Institutes for Biological Sciences
By: Willy Shih, Sen Chai, Kamen Bliznashki and Courtney Hyland
Gordon Zong is trying to teach Chinese universities and research institutes how to do effective technology transfer and IP licensing, but he is trying to do it in an environment with weak property rights and an underdeveloped support infrastructure. As the managing... View Details
Keywords: Multinational Firms and Management; Patents; Knowledge Management; Law Enforcement; Business and Government Relations; Research and Development; Biotechnology Industry; Pharmaceutical Industry; China
Shih, Willy, Sen Chai, Kamen Bliznashki, and Courtney Hyland. "Office of Technology Transfer - Shanghai Institutes for Biological Sciences." Harvard Business School Case 611-057, March 2011. (Revised June 2012.)
- January 2011
- Article
Let the Right One In: A Microeconomic Approach to Partner Choice in Mutualisms
By: Marco Archetti, Francisco Ubeda, Drew Fudenberg, Jerry R. Green, Naomi E. Pierce and Douglas W. Yu
One of the main problems impeding the evolution of cooperation is partner choice. When information is asymmetric (the quality of a potential partner is known only to himself), it may seem that partner choice is not possible without signaling. Many mutualisms, however,... View Details
Keywords: Microeconomics; Strategy; Partners and Partnerships; System; Problems and Challenges; Information; Economics; Theory; Cost; Decision Choices and Conditions; Cooperation
Archetti, Marco, Francisco Ubeda, Drew Fudenberg, Jerry R. Green, Naomi E. Pierce, and Douglas W. Yu. "Let the Right One In: A Microeconomic Approach to Partner Choice in Mutualisms." American Naturalist 177, no. 1 (January 2011).
- May 2007 (Revised September 2008)
- Case
Biocon Limited
By: Krishna G. Palepu and Ananth Chepuri
Biocon Limited was facing significant pricing pressure in their cash cow business, that primarily consisted of manufacturing Active Pharmaceutical Ingredients (APIs). To combat this commoditization, Biocon's leadership had chosen an innovation-led strategy. This new... View Details
Keywords: Globalized Firms and Management; Innovation and Management; Leading Change; Growth and Development Strategy; Risk Management; Organizational Change and Adaptation; Biotechnology Industry; India
Palepu, Krishna G., and Ananth Chepuri. "Biocon Limited." Harvard Business School Case 107-083, May 2007. (Revised September 2008.)
- January 2007 (Revised January 2007)
- Background Note
Note on the U.S. Food and Drug Administration
By: Robert F. Higgins, Richard G. Hamermesh and Virginia Fuller
Describes the U.S. FDA with particular emphasis on its role in the development of new drugs, biologic products, and medical devices today. Provides context for the drug approval process by describing the FDA's history and organizational structure. View Details
Keywords: Health; Governance Compliance; Policy; Product Development; Government and Politics; Pharmaceutical Industry; Medical Devices and Supplies Industry; Biotechnology Industry; Public Administration Industry; United States
Higgins, Robert F., Richard G. Hamermesh, and Virginia Fuller. "Note on the U.S. Food and Drug Administration." Harvard Business School Background Note 807-050, January 2007. (Revised January 2007.)