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    • All HBS Web  (172)
      • Faculty Publications  (30)

      Biologics Remove Biologics →

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      • October 2022
      • Case

      Afrigen Biologics: Vaccines for the Global South

      By: Debora L. Spar and Julia Comeau
      The majority of vaccines used on the continent of Africa (99%) are produced offshore. This makes African nations reliant on the West for major health care needs, a problem which was exacerbated by the COVID-19 pandemic. Afrigen Biologics (in partnership with the WHO)...  View Details
      Keywords: Vaccination; Vaccine; South Africa; mRNA; COVID; COVID-19; Inequity; Hub-and-spoke; Health Care and Treatment; Health Pandemics; Production; Social Issues; Business and Government Relations; South Africa; Africa
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      Spar, Debora L., and Julia Comeau. "Afrigen Biologics: Vaccines for the Global South." Harvard Business School Case 323-030, October 2022.
      • Article

      Biosimilars and Follow-On Products in the United States: Adoption, Prices, and Users

      By: Ariel Dora Stern, Jacqueline L. Chen, Melissa Ouellet, Mark R. Trusheim, Zeid El-Kilani, Amber Jessup and Ernst R. Berndt
      Biologic drugs account for a disproportionate share of the increase in pharmaceutical spending in the U.S. and worldwide. Against this backdrop, many look to the expanding market for biosimilars—follow-on products to biologic drugs—as a vehicle for controlling...  View Details
      Keywords: Pharmaceuticals; Drug Spending; Drug Pricing; Health Care and Treatment; Spending; Price; Markets; Cost Management; United States
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      Stern, Ariel Dora, Jacqueline L. Chen, Melissa Ouellet, Mark R. Trusheim, Zeid El-Kilani, Amber Jessup, and Ernst R. Berndt. "Biosimilars and Follow-On Products in the United States: Adoption, Prices, and Users." Health Affairs 40, no. 6 (June 2021): 989–999.
      • 2021
      • Working Paper

      The Great Unequalizer: Initial Health Effects of COVID-19 in the United States

      By: Marcella Alsan, Amitabh Chandra and Kosali I. Simon
      We measure inequities from the COVID-19 pandemic on mortality and hospitalizations in the United States during the early months of the outbreak. We discuss challenges in measuring health outcomes and health inequality, some of which are specific to COVID-19 and others...  View Details
      Keywords: COVID-19; Health Inequality; Health Pandemics; Demographics; Equality and Inequality
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      Alsan, Marcella, Amitabh Chandra, and Kosali I. Simon. "The Great Unequalizer: Initial Health Effects of COVID-19 in the United States." NBER Working Paper Series, No. 28958, June 2021.
      • 2020
      • Working Paper

      A General Theory of Identification

      By: Iavor Bojinov and Guillaume Basse
      What does it mean to say that a quantity is identifiable from the data? Statisticians seem to agree on a definition in the context of parametric statistical models — roughly, a parameter θ in a model P = {Pθ : θ ∈ Θ} is identifiable if the mapping θ 7→ Pθ is injective....  View Details
      Keywords: Identification; Econometric Models; Analytics and Data Science; Theory
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      Bojinov, Iavor, and Guillaume Basse. "A General Theory of Identification." Harvard Business School Working Paper, No. 20-086, February 2020.
      • September 2019 (Revised August 2020)
      • Case

      Engineering an Inclusive Bioeconomy

      By: Tarun Khanna, Raffaella Sadun and Susie L. Ma
      In 2019, entrepreneur Juan Carlos Castilla-Rubio was developing a project he hoped could generate and share wealth from the natural resources of the Amazon without destroying those resources. His idea, called Earth Bank of Codes (EBC), would create a library of the...  View Details
      Keywords: Decision Making; Development Economics; Entrepreneurship; Innovation and Invention; Intellectual Property; Emerging Markets; Market Design; Marketplace Matching; Science; Genetics; Natural Environment; Environmental Sustainability; Climate Change; Social Enterprise; Strategy; Strategic Planning; Information Technology; Ownership; Social Psychology; Trust; Society; Biotechnology Industry; South America; Amazon Basin
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      Khanna, Tarun, Raffaella Sadun, and Susie L. Ma. "Engineering an Inclusive Bioeconomy." Harvard Business School Case 720-356, September 2019. (Revised August 2020.)
      • March 2019
      • Article

      Crime and Violence: Desensitization in Victims to Watching Criminal Events

      By: Rafael Di Tella, Lucia Freira, Ramiro H. Gálvez, Ernesto Schargrodsky, Diego Shalom and Mariano Sigman
      We study desensitization to crime in a lab experiment by showing footage of criminal acts to a group of subjects, some of whom have been previously victimized. We measure biolog­ical markers of stress and behavioral indices of cognitive control before and after treated...  View Details
      Keywords: Crime; Biological Markers; Experiment; Victimization; Desensitization; Crime and Corruption; Behavior
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      Di Tella, Rafael, Lucia Freira, Ramiro H. Gálvez, Ernesto Schargrodsky, Diego Shalom, and Mariano Sigman. "Crime and Violence: Desensitization in Victims to Watching Criminal Events." Journal of Economic Behavior & Organization 159 (March 2019): 613–625.
      • December 2018 (Revised May 2019)
      • Case

      Darling Ingredients International

      By: David E. Bell and Natalie Kindred
      Led by CEO Randall Stuewe, Texas-based Darling Ingredients International was a rendering firm with $3.7 billion in 2017 revenues. Since 2003, Darling had transformed from U.S. focused into a global player in the processing of biological waste from meat and foodservice...  View Details
      Keywords: Darling; Ingredients; Stuewe; Rendering; Animal Byproducts; Used Cooking Oil; UCO; Diamond Green Diesel; DGD; Valero; Renewable Diesel; Biofuel; Recycling; Carbon; LCFS; Blend; Blender; Strategy; Corporate Strategy; Renewable Energy; Food; Agribusiness; Expansion; Diversification; Growth Management; Technological Innovation; Policy; Government Legislation; Agriculture and Agribusiness Industry; Energy Industry; Food and Beverage Industry; United States; Louisiana; California; Texas
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      Bell, David E., and Natalie Kindred. "Darling Ingredients International." Harvard Business School Case 519-048, December 2018. (Revised May 2019.)
      • 2018
      • Chapter

      The Orphan Drug Act at 35: Observations and an Outlook for the Twenty-First Century

      By: Nicholas Bagley, Benjamin Berger, Amitabh Chandra, Craig Garthwaite and Ariel Dora Stern
      On the 35th anniversary of the adoption of the Orphan Drug Act (ODA), we describe the enormous changes in the markets for therapies for rare diseases that have emerged over recent decades. The most prominent example is the fact that the profit-maximizing price of new...  View Details
      Keywords: Health Care and Treatment; Laws and Statutes; Research and Development; Investment; Markets; Monopoly
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      Bagley, Nicholas, Benjamin Berger, Amitabh Chandra, Craig Garthwaite, and Ariel Dora Stern. "The Orphan Drug Act at 35: Observations and an Outlook for the Twenty-First Century." Chap. 4 in Innovation Policy and the Economy, Volume 19, edited by Josh Lerner and Scott Stern, 97–137. University of Chicago Press, 2018.
      • August 2018
      • Article

      The Impact of the Entry of Biosimilars: Evidence from Europe

      By: Fiona M. Scott Morton, Ariel Dora Stern and Scott Stern
      Biologics represent a substantial and growing share of the U.S. drug market. Traditional “small molecule” generics quickly erode the price and share of the branded product upon entry; however, only a few biosimilars have been approved in the U.S. since 2015, thereby...  View Details
      Keywords: Health Care; Biosimilars; Biologics; Pharmaceutical Competition; Healthcare Spending; Innovation; Health Care and Treatment; Spending; Market Entry and Exit; Competition; Innovation and Invention; Pharmaceutical Industry; United States; Europe
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      Scott Morton, Fiona M., Ariel Dora Stern, and Scott Stern. "The Impact of the Entry of Biosimilars: Evidence from Europe." Review of Industrial Organization 53, no. 1 (August 2018): 173–210.
      • March 2018 (Revised March 2019)
      • Case

      Gender and Free Speech at Google (A)

      By: Nien-hê Hsieh, Martha J. Crawford and Sarah Mehta
      In August 2017, Google fired James Damore, a 28-year-old software engineer who had been employed by the company since 2013. The move came after Damore penned an internal company memo titled “Google’s Ideological Echo Chamber,” which posited that innate biological...  View Details
      Keywords: Free Speech; Representation; Diversity; Gender; Race; Human Resources; Employees; Employee Relationship Management; Recruitment; Selection and Staffing; Labor; Employment; Lawsuits and Litigation; Organizational Culture; Technology Industry; United States; California
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      Hsieh, Nien-hê, Martha J. Crawford, and Sarah Mehta. "Gender and Free Speech at Google (A)." Harvard Business School Case 318-085, March 2018. (Revised March 2019.)
      • 2017
      • Working Paper

      Crime and Violence: Desensitization in Victims to Watching Criminal Events

      By: Rafael Di Tella, Lucía Freira, Ramiro H. Gálvez, Ernesto Schargrodsky, Diego Shalom and Mariano Sigman
      We study desensitization to crime in a lab experiment by showing footage of criminal acts to a group of subjects, some of whom have been previously victimized. We measure biological markers of stress and behavioral indices of cognitive control before and after treated...  View Details
      Keywords: Crime; Biological Markers; Experiment; Victimization; Desensitization; Crime and Corruption; Perspective; Attitudes; Behavior
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      Di Tella, Rafael, Lucía Freira, Ramiro H. Gálvez, Ernesto Schargrodsky, Diego Shalom, and Mariano Sigman. "Crime and Violence: Desensitization in Victims to Watching Criminal Events." Harvard Business School Working Paper, No. 18-039, October 2017.
      • 2017
      • Working Paper

      Crime and Violence: Desensitization in Victims to Watching Criminal Events

      By: Rafael Di Tella, Lucia Freira, Ramiro H. Gálvez, Ernesto Schargrodsky, Diego Shalom and Mariano Sigman
      We study desensitization to crime in a lab experiment by showing footage of criminal acts to a group of subjects, some of whom have been previously victimized. We measure biological markers of stress and behavioral indices of cognitive control before and after treated...  View Details
      Keywords: Crime and Corruption; Attitudes; Perspective; Behavior
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      Di Tella, Rafael, Lucia Freira, Ramiro H. Gálvez, Ernesto Schargrodsky, Diego Shalom, and Mariano Sigman. "Crime and Violence: Desensitization in Victims to Watching Criminal Events." NBER Working Paper Series, No. 23697, August 2017.
      • November 2016
      • Case

      QuintilesIMS: Biosimilar Marketing in England

      By: John A. Quelch and Emily C. Boudreau
      QuintilesIMS was a leading healthcare consulting firm best known for its data and information offerings as well as its market research and management consulting services for life science companies. By 2015, the company was expanding beyond the biopharmaceutical...  View Details
      Keywords: Health; Pharmaceutical Industry; Biotech; Marketing; Health Care and Treatment; Biotechnology Industry; England
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      Quelch, John A., and Emily C. Boudreau. "QuintilesIMS: Biosimilar Marketing in England." Harvard Business School Case 517-054, November 2016.
      • June 2016 (Revised August 2019)
      • Case

      Numenta: Inventing and (or) Commercializing AI

      By: David B. Yoffie, Liz Kind and David Ben Shimol
      In March 2016, Donna Dubinsky (co-founder and CEO) and Jeff Hawkins (co-founder) were struggling with a key question: Could Numenta be successful in both creating fundamental technology and building a commercial business? Located in Redwood City, CA, Numenta was...  View Details
      Keywords: Artificial Intelligence; Machine Intelligence; Machine Learning; Strategy; Business Model; Entrepreneurship; Information; Technological Innovation; Research; Research and Development; Information Technology; Applications and Software; Technology Adoption; Digital Platforms; Commercialization; AI and Machine Learning
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      Yoffie, David B., Liz Kind, and David Ben Shimol. "Numenta: Inventing and (or) Commercializing AI." Harvard Business School Case 716-469, June 2016. (Revised August 2019.)
      • October 2015
      • Article

      Hormones and Ethics: Understanding the Biological Basis of Unethical Conduct

      By: Jooa Julie Lee, Francesca Gino, Ellie Shuo Jin, Leslie K. Rice and Robert A. Josephs
      Globally, fraud has been rising sharply over the last decade, with current estimates placing financial losses at greater than $3.7 trillion dollars annually. Unfortunately, fraud prevention has been stymied by lack of a clear and comprehensive understanding of its...  View Details
      Keywords: Behavior; Ethics; Science
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      Lee, Jooa Julie, Francesca Gino, Ellie Shuo Jin, Leslie K. Rice, and Robert A. Josephs. "Hormones and Ethics: Understanding the Biological Basis of Unethical Conduct." Journal of Experimental Psychology: General 144, no. 5 (October 2015): 891–897.
      • Article

      No Evidence For an Effect of Testosterone Administration on Delay Discounting in Male University Students

      By: Georgia Rada Ortner, Matthias Wibral, Anke Becker, Thomas Dohmen, Dietrich Klingmüller, Armin Falk and Bernd Weber
      Intertemporal choices between a smaller sooner and a larger delayed reward are one of the most important types of decisions humans face in their everyday life. The degree to which individuals discount delayed rewards correlates with impulsiveness. Steep delay...  View Details
      Keywords: Delay Discounting; Impulsiveness; Intertemporal Choice; Testosterone; Decision Making; Behavior; Personal Characteristics
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      Rada Ortner, Georgia, Matthias Wibral, Anke Becker, Thomas Dohmen, Dietrich Klingmüller, Armin Falk, and Bernd Weber. "No Evidence For an Effect of Testosterone Administration on Delay Discounting in Male University Students." Psychoneuroendocrinology 38, no. 9 (September 2013): 1814–1818.
      • July 2011 (Revised January 2013)
      • Case

      Digital Microscopy Is Making Me Crazy!

      By: Willy Shih
      For Carl Zeiss Microimaging, modular hardware and software enabled customers to tailor Zeiss's broad range of microscopy systems hardware and software to meet a wide range of needs from basic scientific research in the biological and medical sciences to clinical...  View Details
      Keywords: Information Infrastructure; Applications and Software; Corporate Strategy; Disruptive Innovation; Science-Based Business; Management Analysis, Tools, and Techniques; Business Conglomerates; Digital Platforms; Opportunities; Medical Devices and Supplies Industry; Computer Industry
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      Shih, Willy. "Digital Microscopy Is Making Me Crazy!" Harvard Business School Case 612-002, July 2011. (Revised January 2013.)
      • April 2011
      • Teaching Note

      Office of Technology Transfer - Shanghai Institutes for Biological Sciences (TN)

      By: Willy Shih and Sen Chai
      Teaching Note for 611057.  View Details
      Keywords: Patents; Rights; Infrastructure; Multinational Firms and Management; Research and Development; Complexity; Commercialization; Technology Adoption; Motivation and Incentives; Biotechnology Industry; Pharmaceutical Industry; Shanghai
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      Shih, Willy, and Sen Chai. "Office of Technology Transfer - Shanghai Institutes for Biological Sciences (TN)." Harvard Business School Teaching Note 611-058, April 2011.
      • March 2011 (Revised June 2012)
      • Case

      Office of Technology Transfer - Shanghai Institutes for Biological Sciences

      By: Willy Shih, Sen Chai, Kamen Bliznashki and Courtney Hyland
      Gordon Zong is trying to teach Chinese universities and research institutes how to do effective technology transfer and IP licensing, but he is trying to do it in an environment with weak property rights and an underdeveloped support infrastructure. As the managing...  View Details
      Keywords: Multinational Firms and Management; Patents; Knowledge Management; Law Enforcement; Business and Government Relations; Research and Development; Biotechnology Industry; Pharmaceutical Industry; China
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      Shih, Willy, Sen Chai, Kamen Bliznashki, and Courtney Hyland. "Office of Technology Transfer - Shanghai Institutes for Biological Sciences." Harvard Business School Case 611-057, March 2011. (Revised June 2012.)
      • January 2011
      • Article

      Let the Right One In: A Microeconomic Approach to Partner Choice in Mutualisms

      By: Marco Archetti, Francisco Ubeda, Drew Fudenberg, Jerry R. Green, Naomi E. Pierce and Douglas W. Yu
      One of the main problems impeding the evolution of cooperation is partner choice. When information is asymmetric (the quality of a potential partner is known only to himself), it may seem that partner choice is not possible without signaling. Many mutualisms, however,...  View Details
      Keywords: Microeconomics; Strategy; Partners and Partnerships; System; Problems and Challenges; Information; Economics; Theory; Cost; Decision Choices and Conditions; Cooperation
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      Archetti, Marco, Francisco Ubeda, Drew Fudenberg, Jerry R. Green, Naomi E. Pierce, and Douglas W. Yu. "Let the Right One In: A Microeconomic Approach to Partner Choice in Mutualisms." American Naturalist 177, no. 1 (January 2011).
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