Chimeric Antigen Receptor (CAR) T-Cell Therapy: Case Histories of Significant Medical Advances

Amar  Bhidé; Srikant M. Datar

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Working Paper | HBS Working Paper Series | 2020

Chimeric Antigen Receptor (CAR) T-Cell Therapy: Case Histories of Significant Medical Advances

by Amar Bhidé and Srikant M. Datar

Abstract

In 2017, the US Food and Drug Administration (FDA) approved an immunotherapeutic treatment, called CAR-T therapy, for two kinds of blood cancers—acute leukemia (ALL) and a lymphoma. We describe 1) how CAR-T works; 2) the foundational advances and discoveries; 3) development of CAR-T therapy; and 4) the situation in 2019.

Keywords: immunotherapy; Health Care and Treatment; Innovation and Invention; Research and Development; Governing Rules, Regulations, and Reforms;

Language: English

Format: Print

25 pages

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Citation:

Bhidé, Amar, and Srikant M. Datar. "Chimeric Antigen Receptor (CAR) T-Cell Therapy: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 21-034, August 2020.

About the Authors

Amar Bhide

Visiting Professor of Business Administration

General Management

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Srikant M. Datar

Arthur Lowes Dickinson Professor of Business Administration
Senior Associate Dean for University Affairs

Accounting and Management

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Working Paper | HBS Working Paper Series | 1992

Employment versus Sub-Contracting: The Real Trade-Offs

Amar Bhide and Howard Stevenson

By many accounts, sub-contracting is in the vogue while traditional employment relationships are on the outs. Ten years ago free-lancers, independent subcontractors and the like accounted for about 10 percent of the labor force; today they constitute 25 percent. Of the 23 million net new jobs generated in the U.S. since 1974, 60 percent have been for free-lancers and subcontractors. The phenomenon appears especially strong in the large publicly traded firms - while revenue growth in Fortune 500 companies has kept up with GNP, these companies have added virtually no new jobs since the early 1970s and have increasingly become what BusinessWeek calls "hollow corporations".

Keywords: sub-contracting; freelancers; Employment; Organizations; Theory;

Citation:
Bhide, Amar, and Howard Stevenson. "Employment versus Sub-Contracting: The Real Trade-Offs." Harvard Business School Working Paper, No. 88-046, March 1987. (Revised March 1992.) View Details

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Working Paper | HBS Working Paper Series | 2015

On the Increasing Centralization of US Money and Credit

Amar Bhidé

My current work on the debt market liquidity (Bhidé 2015) and antecedent book (Bhidé 2010) critiques the de facto centralization of credit extension in the U.S. This essay examines how the increased centralization of credit maps into a decline in the decentralized production of money and the dysfunction this entails.

Keywords: centralization; Money; Credit; United States;

Citation:
Bhidé, Amar. "On the Increasing Centralization of US Money and Credit." Harvard Business School Working Paper, No. 21-022, June 2015. View Details

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Working Paper | HBS Working Paper Series | 2020

Building the Professional Firm: McKinsey & Co.: 1939-1968

Amar Bhidé

This case history analyzes how the founders of McKinsey & Co. built one of the world's leading management consulting firms by developing a “system” of professional norms, approach to serving clients, personnel policies, organization, governance, and ownership. The history also shows that while McKinsey’s founders resorted to considerable trial and error, it was not ad hoc: they intended to discover the best means to further a long-term vision and strategy. Moreover, their vision and strategy derived more from a priori faith and personal values than from scientific evidence or financial calculation.

Keywords: McKinsey ＆ Co.; company history; professional norms; vision; Organizations; Business History; Business Model; Strategy; Consulting Industry;

Citation:
Bhidé, Amar. "Building the Professional Firm: McKinsey & Co.: 1939-1968." Harvard Business School Working Paper, No. 95-010, January 1995. (Revised July 2020.) View Details

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Chimeric Antigen Receptor (CAR) T-Cell Therapy: Case Histories of Significant Medical Advances

Abstract

Citation:

About the Authors

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