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Case | HBS Case Collection | January 2018

Spark Therapeutics: Pioneering Gene Therapy

by Robert F. Higgins and Tina Liu

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Abstract

Spark Therapeutics is a pioneering gene therapy startup. It was spun out of The Children’s Hospital of Philadelphia (CHOP). The company had taken with it much of the intellectual property and talent that CHOP had developed. The company is considering an initial public offering. In addition, several large pharma companies have expressed interest in partnering with Spark to develop its hemophilia B program. Also, the company is working with the FDA on a potential change to its protocol. The CEO is preparing for a board meeting, and he is contemplating the best path to deal with these challenges and opportunities.

Keywords: Health Care and Treatment; Innovation and Invention; Business Startups; Opportunities; Problems and Challenges; Strategy;

Language: English Format: Print 27 pages EducatorsPurchase

Citation:

Higgins, Robert F., and Tina Liu. "Spark Therapeutics: Pioneering Gene Therapy." Harvard Business School Case 818-059, January 2018.

About the Author

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Robert F. Higgins
Senior Lecturer of Business Administration
Entrepreneurial Management

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  • Case | HBS Case Collection | January 2019 (Revised January 2019)

    An eSports Profile: Team Liquid & aXiomatic

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    Citation:

    Higgins, Robert F., and James Barnett. "An eSports Profile: Team Liquid & aXiomatic." Harvard Business School Case 819-076, January 2019. (Revised January 2019.)  View Details
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  • Supplement | HBS Case Collection | December 2018

    Michael Rubin and Fanatics (B)

    Robert F. Higgins and John Masko

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    Higgins, Robert F., and John Masko. "Michael Rubin and Fanatics (B)." Harvard Business School Supplement 819-082, December 2018.  View Details
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  • Case | HBS Case Collection | December 2018

    DraftKings and the Future of Fantasy Sports

    Robert F. Higgins and Julia Kelley

    Founded in 2012, DraftKings helped change the fantasy sports landscape by popularizing daily fantasy sports (DFS), or short-term fantasy sports tournaments that offered big cash prizes to winners. The company’s valuation exceeded $1 billion by 2015, but DraftKings soon faced intense scrutiny from government agencies about whether its business model violated federal laws preventing sports betting and online gambling. Then, in May 2018, the U.S. Supreme Court overturned a federal law that had prohibited states from legalizing sports betting. Now that states could legalize sports betting, what should DraftKings’ next steps be?

    Keywords: Fantasy Sports; Daily Fantasy Sports; DraftKings; FanDuel; supreme court; Sports Betting; Sports Gambling; Sports; Business Model; Government Legislation; Lawsuits and Litigation; Laws and Statutes; Business Strategy; Online Technology; Mobile Technology; Games, Gaming, and Gambling; Sports Industry; Entertainment and Recreation Industry; United States; Massachusetts; Boston;

    Citation:

    Higgins, Robert F., and Julia Kelley. "DraftKings and the Future of Fantasy Sports." Harvard Business School Case 819-074, December 2018.  View Details
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