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• Article | Clinical Pharmacology & Therapeutics | January 2018

  Innovation Incentives and Biomarkers

  Ariel Dora Stern, Brian M. Alexander and Amitabh Chandra

  Previously, we have discussed the importance of economic incentives in shaping markets for precision medicines. Here we consider incentives for biomarker development, including discovery and establishment. Biomarkers can reveal valuable information regarding diagnosis and prognosis, predict treatment efficacy or toxicity, serve as markers of disease progression, and serve as auxiliary endpoints for clinical trials. Some have multiple uses, while others have a specialized role, resulting in diverse incentives across players in the healthcare system.

  Keywords: Health Care and Treatment; Innovation and Invention; Research and Development; Markets;

  Citation:

  Stern, Ariel Dora, Brian M. Alexander, and Amitabh Chandra. "Innovation Incentives and Biomarkers." Clinical Pharmacology & Therapeutics 103, no. 1 (January 2018): 34–36.  View Details

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• Case | HBS Case Collection | June 2008 (Revised December 2017)

  Yataro Iwasaki: Founding Mitsubishi (A)

  Geoffrey Jones, Masako Egawa and Mayuka Yamazaki

  Considers the entrepreneurial career of the founder of Mitsubishi, Yataro Iwasaki, who built a large shipping company against the opposition of powerful Western incumbents. Although sometimes supported by the Japanese government, and often times opposed, the case identifies Iwasaki's entrepreneurial talent and organization-building skills as key drivers of success. This case provides a vehicle for examining the entrepreneurial factors behind Japan's remarkable transition from a feudal to a modern society in the second half of the nineteenth century.

  Keywords: History; Leadership; Business History; Organizational Structure; Entrepreneurship; Business and Government Relations; Japan;

  Citation:

  Jones, Geoffrey, Masako Egawa, and Mayuka Yamazaki. "Yataro Iwasaki: Founding Mitsubishi (A)." Harvard Business School Case 808-158, June 2008. (Revised December 2017.)  View Details

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• Case | HBS Case Collection | September 2017 (Revised December 2017)

  Henry Kissinger: Negotiating Black Majority Rule in Rhodesia (A)

  James K. Sebenius and Laurence A. Green

  In 1976, a growing crisis in Southern Africa drew the attention of United States Secretary of State Henry A. Kissinger. White Rhodesian leader Ian Smith's refusal to accede to black majority rule threatened to widen into a regional conflict involving apartheid South Africa and newly independent leftist African states. Kissinger and others feared that the region was on the brink of becoming a new battleground in the Cold War. In light of these developments Kissinger decided to intervene, seeking a negotiated solution that might bring about a peaceful end to minority rule. The account in this case carefully describes—but does not analyze nor draw lessons from—these challenging circumstances.

  Keywords: equality and inequality; Negotiation Process; race; Negotiation Participants; Government and Politics; Africa; United States; Equality and Inequality; Race; Negotiation Process; Negotiation Participants; Government and Politics; Africa; United States;

  Citation:

  Sebenius, James K., and Laurence A. Green. "Henry Kissinger: Negotiating Black Majority Rule in Rhodesia (A)." Harvard Business School Case 918-003, September 2017. (Revised December 2017.)  View Details

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