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• Case | HBS Case Collection | June 2020

  Breakthroughs at Blueprint Medicines

  Richard G. Hamermesh, Kathy Giusti and Susie L. Ma

  Precision medicine company Blueprint Medicines was building a successful track record for bringing drug therapies to market 40% faster than average. The company had spent $40 million dollars and two years building a compound library that became its drug development engine. Blueprint’s drug development strategy was twofold—it focused on creating a single drug compound for multiple disease indications, while at the same time developing drugs to track a disease through its progression. The company’s goal was to become a fully integrated biopharmaceutical company that could move from drug discovery to development to marketing. But it was increasingly challenging to prioritize and manage programs, personnel and partnerships.

  Keywords: precision medicine; cancer; biotechnology; drug development; Strategy; Expansion; Science; Genetics; Technology; Entrepreneurship; Organizational Culture; Management; Growth and Development; Pharmaceutical Industry; United States; Cambridge; Massachusetts;

  Citation:

  Hamermesh, Richard G., Kathy Giusti, and Susie L. Ma. "Breakthroughs at Blueprint Medicines." Harvard Business School Case 820-001, June 2020.  View Details

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• Case | HBS Case Collection | December 2019 (Revised June 2020)

  The New LAX: Ready for Takeoff?

  Boris Groysberg, Kerry Herman and Carin-Isabel Knoop

  Chair of LAX Board Sean Burton and LAX CEO Deborah Flint have made progress on streamlining and modernizing LAX's complex capital projects ($12 billion worth) while reorganizing and retooling Los Angeles World Airport (LAWA) staff resources, management processes, and revitalizing the LAX guest experience. From 2015 to 2019, LAX's performance improved, yet many challenges remained, and new ones continued to come to light. In December 2019, as Flint prepared to move onto a new position, Burton and the board are assessing the progress the team has made, and looking to next steps.

  Keywords: Leadership and Change Management; Leadership; Change Management; Performance Improvement; Strategic Planning; Air Transportation; Outcome or Result; Air Transportation Industry; Los Angeles;

  Citation:

  Groysberg, Boris, Kerry Herman, and Carin-Isabel Knoop. "The New LAX: Ready for Takeoff?" Harvard Business School Case 420-025, December 2019. (Revised June 2020.)  View Details

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• Teaching Note | HBS Case Collection | June 2020

  The New LAX: Ready for Takeoff?

  Boris Groysberg, Carin-Isabel Knoop, Kerry Herman and Amy Klopfenstein

  This teaching note serves as a supplement to “The New LAX: Ready for Takeoff?” HBS 420-025.

  Keywords: Change; Change Management; Transformation; Leadership; Leading Change; Leadership Style; Management; Management Practices and Processes; Management Succession; Organizations; Organizational Culture; Organizational Change and Adaptation; Mission and Purpose; Strategy; Alignment; Transportation; Air Transportation; Transportation Networks; Air Transportation Industry; North and Central America; United States; California; Los Angeles;

  Citation:

  Groysberg, Boris, Carin-Isabel Knoop, Kerry Herman, and Amy Klopfenstein. "The New LAX: Ready for Takeoff?" Harvard Business School Teaching Note 420-091, June 2020.  View Details

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