Design and Implementation of a Privacy Preserving Electronic Health Record Linkage Tool in Chicago

Abel  Kho; John  Cashy; Kathryn  Jackson; Adam  Pah; Satyender  Goel; Jorn  Boehnke; John Eric  Humphries; Scott Duke Kominers; et  al.

Article | Journal of the American Medical Informatics Association | September 2015

Design and Implementation of a Privacy Preserving Electronic Health Record Linkage Tool in Chicago

by Abel Kho, John Cashy, Kathryn Jackson, Adam Pah, Satyender Goel, Jorn Boehnke, John Eric Humphries, Scott Duke Kominers and et al.

Abstract

Objective
To design and implement a tool that creates a secure, privacy preserving linkage of electronic health record (EHR) data across multiple sites in a large metropolitan area in the United States (Chicago, IL), for use in clinical research.
Methods
The authors developed and distributed a software application that performs standardized data cleaning, preprocessing, and hashing of patient identifiers to remove all protected health information. The application creates seeded hash code combinations of patient identifiers using a Health Insurance Portability and Accountability Act compliant SHA-512 algorithm that minimizes re-identification risk. The authors subsequently linked individual records using a central honest broker with an algorithm that assigns weights to hash combinations in order to generate high specificity matches.
Results
The software application successfully linked and de-duplicated 7 million records across 6 institutions, resulting in a cohort of 5 million unique records. Using a manually reconciled set of 11 292 patients as a gold standard, the software achieved a sensitivity of 96% and a specificity of 100%, with a majority of the missed matches accounted for by patients with both a missing social security number and last name change. Using 3 disease examples, it is demonstrated that the software can reduce duplication of patient records across sites by as much as 28%.
Conclusions
Software that standardizes the assignment of a unique seeded hash identifier merged through an agreed upon third-party honest broker can enable large-scale secure linkage of EHR data for epidemiologic and public health research. The software algorithm can improve future epidemiologic research by providing more comprehensive data given that patients may make use of multiple healthcare systems.

Keywords: Information; Customers; Safety; Rights; Ethics; Entrepreneurship; Health Care and Treatment; Health Industry; Chicago;

Format: Print

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Citation:

Kho, Abel, John Cashy, Kathryn Jackson, Adam Pah, Satyender Goel, Jorn Boehnke, John Eric Humphries, Scott Duke Kominers, and et al. "Design and Implementation of a Privacy Preserving Electronic Health Record Linkage Tool in Chicago." Journal of the American Medical Informatics Association 22, no. 5 (September 2015): 1072–1080.

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Design and Implementation of a Privacy Preserving Electronic Health Record Linkage Tool in Chicago

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